Identification of the multiple endocrine neoplasia type. 1 (MEN1) gene. The European Consortium on MEN1: Belgium: Irma Lemmens1, Wim J. M. Van de Ven1, ...
1997 Oxford University Press
Human Molecular Genetics, 1997, Vol. 6, No. 7
1177–1183
Identification of the multiple endocrine neoplasia type 1 (MEN1) gene The European Consortium on MEN1: Belgium: Irma Lemmens1, Wim J. M. Van de Ven1, Koen Kas1, France (Lyon): Chang X. Zhang2,3, Sophie Giraud2, Virginie Wautot3, Nathalie Buisson2,3, Ko De Witte3, Janine Salandre2, Gilbert Lenoir2,3, Michel Pugeat4, Alain Calender2,3, France (Nice): Fabienne Parente5, Danielle Quincey5, Patrick Gaudray5, Netherlands: Mireille J. De Wit6, Cornelis J. M. Lips6, Jo W. M. Höppener6, Sweden: Shideh Khodaei7, Abby L. Grant7, Günther Weber7, Sweden: Soili Kytölä8,9, Bin T. Teh8, Filip Farnebo8, Catherine Phelan8, Nicholas Hayward10, Catharina Larsson8, UK: Anna A. J. Pannett11,+, Simon A. Forbes11,+, J. H. Duncan Bassett11,+ and Rajesh V. Thakker11,* 1Laboratory
for Molecular Oncology and Flanders Interuniversity Institute for Biotechnology, Center for Human Genetics, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium, 2,3,4GENEM 1 (Groupe d’Etude des Néoplasies Endocriniennes Multiples de type 1): 2Genetic Unit, Hôpital Edouard Herriot, 3Laboratory of genetics and cancer, CNRS UMR5641, Medical University Claude Bernard Lyon I, 4Endocrinology Unit, Hôpital de l’Antiquaille - 69 Lyon, France, 5Instabilité et altérations des Génomes, UNSA/CNRS UMR 6549, Avenue de Valombrose 06107 Nice, France, 6Utrecht University Hospital, Departments of Internal Medicine and Pathology, H04–313, PO Box 85500, Heidelberglaan 100, 3508 GA Utrecht, Netherlands, 7Department of Molecular Medicine, Karolinska Hospital, Clinical Genetics Unit, CMM L8:02, S-171 76 Stockholm, Sweden, 8Department of Molecular Medicine, Endocrine tumour unit, Karolinska Hospital, CMM L8:01, S-171 76 Stockholm, Sweden, 9Department of Clinical Genetics, Oulu University Hospital, Oulu, Finland, 10Queensland Institute of Medical Research, Human Genetics Laboratory, Herston 4029, Queensland, Australia and 11MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK Received April 25, 1997; Revised and Accepted May 6, 1997
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by tumours of the parathyroids, pancreas and anterior pituitary that represents one of the familial cancer syndromes. The MEN1 locus has been previously localised to chromosome 11q13, and a
