Impact of Cocaine Use on Acute Ischemic Stroke ...

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Aug 2, 2017 -
Open Access Original Article

DOI: 10.7759/cureus.1536

Impact of Cocaine Use on Acute Ischemic Stroke Patients: Insights from Nationwide Inpatient Sample in the United States Rupak Desai 1 , Upenkumar Patel 2 , Chintan Rupareliya 3 , Sandeep Singh 4 , Manan Shah 5 , Rikinkumar Patel 6 , Smit Patel 7 , Zabeen Mahuwala 8 1. Research Coordinator, Atlanta Veterans Affairs Medical Center 2. Public Health, National University 3. Department of Neurology, University of Missouri, Columbia, Missouri 4. Neurology, IHBAS 5. Internal Medicine, UT Houston 6. Public Health, Arcadia University 7. Department of Neurology, University of Connecticut Health Center 8. Department of Neurology, University Of Kentucky College of Medicine  Corresponding author: Chintan Rupareliya, [email protected] Disclosures can be found in Additional Information at the end of the article


Received 07/12/2017 Review began 07/26/2017

Cocaine is the third most common substance of abuse after cannabis and alcohol. The use of cocaine as an illicit substance is implicated as a causative factor for multisystem derangements ranging from an acute crisis to chronic complications. Vasospasm is the proposed mechanism behind adverse events resulting from cocaine abuse, acute ischemic strokes (AIS) being one of the few. Our study looked into in-hospital outcomes owing to cocaine use in the large population based study of AIS patients. Using the national inpatient sample (NIS) database from 2014 of United States of America, we identified AIS patients with cocaine use using International Classification of Disease, Ninth Revision (ICD-9) codes. We compared demographics, mortality, in-hospital outcomes and comorbidities between AIS with cocaine use cohort versus AIS without cocaine use cohort. Acute ischemic strokes (AIS) with cocaine group consisted of higher number of older patients (> 85 years) (25.6% versus 18.7%, p