bronchodilatation in normal individuals.21. The. Vrc and flaw measurements were repeated at 10 to 20 mm after the end of nebulization. Statistical. Analysis. The.
Cholinergic bronchomotor tone and airway caliber in insulin-dependent diabetes mellitus. C M Santos e Fonseca, J C Manço, L Gallo Júnior, A A Barreira and M C Foss Chest 1992;101;1038-1043 DOI 10.1378/chest.101.4.1038 The online version of this article, along with updated information and services can be found online on the World Wide Web at: http://chestjournal.chestpubs.org/content/101/4/1038
Chest is the official journal of the American College of Chest Physicians. It has been published monthly since 1935. Copyright1992by the American College of Chest Physicians, 3300 Dundee Road, Northbrook, IL 60062. All rights reserved. No part of this article or PDF may be reproduced or distributed without the prior written permission of the copyright holder. (http://chestjournal.chestpubs.org/site/misc/reprints.xhtml) ISSN:0012-3692
Cholinergic Broncbomotor Tone and Airway Caliber in Insulin-Dependent Diabetes Mellitus* Concei#{231}do
MC.
Santos e Fonseca, Jr., M.D., Ph.D.;t C. Fos M.D. Ph.D.t
Louren#{231}o Gallo,
and
Milton
M.D.;t Jos#{233} C. Man#{231}o,M.D., Amilton A. Barreira, M.D.,
,
It has
been suggested that the autonomic bronchomotor tone may be altered in diabetes. In the present study, we assessed the cholinergic bronchomotor tone in 34 insulindependent diabetic patients and in a control group of 32 healthy subjects (group C). As an index of the intensity of cholinergic tone to the airways, we measured the increase in specific airway conductance (GawNL) induced by aerosol administration of atropine sulfate. In all ofthe patients and normal individuals the autonomic cardiovascular activity was also evaluated by the tilting test and by the magnitude of the respiratory sinus arrhythmia (RSA). In 19 patients without symptoms of autonomic neuropathy (AN) (group D-1), the autonomic cardiovascular activity was comparable to that of group C. The other 15 patients presented with at least one symptom of AN and a depressed heart rate (HR) control when submitted to the tests of autonomic activity (group D-2). Before atropine administration, Gaw/VL was significantly higher (p
