Feb 12, 2014 - Glutathione (GSH) and the GSH synthesis gene Gclm modulate plasma redox and vascular responses to acute diesel exhaust inhalation in ...
In Utero Exposure to Diesel Exhaust Air Pollution Promotes Adverse Intrauterine Conditions, Resulting in Weight Gain, Altered Blood Pressure, and Increased Susceptibility to Heart Failure in Adult Mice Chad S. Weldy1,2, Yonggang Liu1, H. Denny Liggitt3, Michael T. Chin1,2* 1 Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, 2 Department of Pathology, University of Washington School of Medicine, Seattle, Washington, United States of America, 3 Department of Comparative Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
Abstract Exposure to fine particulate air pollution (PM2.5) is strongly associated with cardiovascular morbidity and mortality. Exposure to PM2.5 during pregnancy promotes reduced birthweight, and the associated adverse intrauterine conditions may also promote adult risk of cardiovascular disease. Here, we investigated the potential for in utero exposure to diesel exhaust (DE) air pollution, a major source of urban PM2.5, to promote adverse intrauterine conditions and influence adult susceptibility to disease. We exposed pregnant female C57Bl/6J mice to DE (
