Mar 25, 2015 - Abstract The present study explored the phytochemical screening, in vitro antimicrobial activity, in vivo antiemetic and antinociceptive ...
In vitro antimicrobial activity study and in vivo antiemetic, antinociceptive activity evaluation of leaves extract of Erioglossum rubiginosum using experimental animal model Amirul Islam Sajib, Syed Masudur Rahman Dewan, Abhijit Das, Md. Shahid Sarwar, Rakhesh Chandra Sarkar, Maizbha Uddin Ahmed, et al. Oriental Pharmacy and Experimental Medicine ISSN 1598-2386 Volume 15 Number 2 Orient Pharm Exp Med (2015) 15:135-140 DOI 10.1007/s13596-015-0181-y
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Author's personal copy Orient Pharm Exp Med (2015) 15:135–140 DOI 10.1007/s13596-015-0181-y
Online ISSN 2211-1069 Print ISSN 1598-2386
RESEARCH ARTICLE
In vitro antimicrobial activity study and in vivo antiemetic, antinociceptive activity evaluation of leaves extract of Erioglossum rubiginosum using experimental animal model Amirul Islam Sajib & Syed Masudur Rahman Dewan & Abhijit Das & Md. Shahid Sarwar & Rakhesh Chandra Sarkar & Maizbha Uddin Ahmed & Mohammad Safiqul Islam
Received: 20 March 2014 / Accepted: 23 February 2015 / Published online: 25 March 2015 # Institute of Korean Medicine, Kyung Hee University and Springer Science+Business Media Dordrecht 2015
Abstract The present study explored the phytochemical screening, in vitro antimicrobial activity, in vivo antiemetic and antinociceptive potentialities of methanol extract of Erioglossum rubiginosum leaves for the first time. Crude extract of E. rubiginosum and different fractions were assayed for in vitro antimicrobial activity using disc diffusion method. The antiemetic activity was evaluated using chick emesis model; while acetic acid induced writhing test in mice was conducted to determine the antinociceptive activity. Different extracts possess carbohydrate, flavonoids, saponin, tannin, alkaloids, phenol and cardiac-glycoside in varying concentrations. Among different extractives, only the chloroform soluble fraction showed promising antimicrobial activity (zone of inhibition 6.5 to 10 mm) in comparison to positive control−ciprofloxacin, against wide range of tested microorganisms. In antiemetic assay, all the extracts showed significant (P
