Journal of Cancer 2018, Vol. 9
Ivyspring
International Publisher
959
Journal of Cancer 2018; 9(6): 959-967. doi: 10.7150/jca.22787
Research Paper
Increased Paxillin expression in prostate cancer is associated with advanced pathological features, lymph node metastases and biochemical recurrence Qing-Shui Zheng1*, Shao-Hao Chen1*, Yu-Peng Wu1*, Hui-Jun Chen1, Hong Chen2, Yong Wei1, Xiao-Dong Li1, Jin-Bei Huang1, Xue-Yi Xue1, Ning Xu1 1. 2.
Departments of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China Departments of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
* Contributed equally Corresponding authors: Ning Xu (
[email protected]) and Xue-Yi Xue (
[email protected]), Department of Urology, The First Affiliated Hospital of Fujian Medical University. No. 20 Chazhong Road, Fuzhou 350005, China. Tel/Fax: +86-059187981687 © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Received: 2017.09.11; Accepted: 2018.01.31; Published: 2018.02.28
Abstract Purpose Paxillin regulates cell-cell adhesion, and altered Paxillin expression has been associated with human carcinogenesis. This study analyzed the association between Paxillin expression in prostate cancer (PCa) tissues with clinicopathological features, lymph node metastasis and biochemical PCa recurrence. Methods A total of 386 tissue specimens from PCa patients who received radical prostatectomy and 60 tissue specimens from benign prostatic hyperplasia (BPH) cases were collected to construct tissue microarrays, which were subsequently immunostained for Paxillin expression. Thirty positive lymph node tissue specimens and 10 healthy prostate tissue specimens were randomly selected for Paxillin immunostaining. Results The association between Paxillin expression, lymph node metastasis and biochemical PCa recurrence was analyzed. Paxillin expression was significantly higher in PCa than both normal and BPH tissues (P
