J Neuroimmune Pharmacol DOI 10.1007/s11481-013-9487-z
ORIGINAL ARTICLE
Induction of Experimental Autoimmune Encephalomyelitis With Recombinant Human Myelin Oligodendrocyte Glycoprotein in Incomplete Freund’s Adjuvant in Three Non-human Primate Species Krista G. Haanstra & S. Anwar Jagessar & Anne-Laure Bauchet & Mireille Doussau & Claire-Maëlle Fovet & Nicole Heijmans & Sam O. Hofman & Jennifer van Lubeek-Veth & Jeffrey J. Bajramovic & Yolanda S. Kap & Jon D. Laman & Hélène Touin & Laurent Watroba & Jan Bauer & François Lachapelle & Che Serguera & Bert A. ’t Hart Received: 14 June 2013 / Accepted: 17 June 2013 # The Author(s) 2013. This article is published with open access at Springerlink.com
Abstract The experimental autoimmune encephalitis (EAE) model is used for preclinical research into the pathogenesis of multiple sclerosis (MS), mostly in inbred, specific pathogen free (SPF)-raised laboratory mice. However, the naive state of the laboratory mouse immune system is considered a major Krista G. Haanstra, S. Anwar Jagessar and Anne-Laure Bauchet contributed equally to the study. Che Serguera and Bert A. ’t Hart share senior authorship.
K. G. Haanstra : S. A. Jagessar : N. Heijmans : S. O. Hofman : Y. S. Kap : B. A. ’t Hart (*) Department of Immunobiology, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands e-mail:
[email protected] S. A. Jagessar : J. D. Laman : B. A. ’t Hart Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands A.
