Infliximab compliance estimates from medical chart ... - Value in Health
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Infliximab compliance estimates from medical chart ... - Value in Health
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VALUE IN HEALTH 16 (2013) A1-A298
OBJECTIVES: To investigate the usefulness of National Health and Nutrition Examination Survey (NHANES) data for exposure estimates. To illustrate its utility, the relationship between biomarkers of exposure (serum cotinine) and cardiovascular disease (WBC, Apo lipoprotein, C-reactive protein, HDL, LDL, total cholesterol) among current, past, and non smokers was examined using NHANES 2007-2010. METHODS: Data were obtained from NHANES 2007 to 2010. The study sample had 11, 960 respondents who were 21 years and above, answered questions on cigarette smoking and had complete laboratory values for their biomarkers measurement. The population was categorized as current, past, and non smokers. The exposure variable was serum cotinine concentration and the outcome variables were serum levels of the biomarkers listed above. Weighted survey linear regression was used to estimate the association between cotinine concentration and biomarkers levels. We also tested the models for different levels of covariates; age, sex, race and body mass index (BMI). RESULTS: The levels of WBC (F-value: 38.78; P-value:
