May 13, 2008 - to the Warburg effect observed in tumor cells, starving yeast auxotrophs wastes glucose as a consequence of the failure of conserved growth ...
Influence of genotype and nutrition on survival and metabolism of starving yeast Viktor M. Boer, Sasan Amini, and David Botstein* Lewis–Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544 Contributed by David Botstein, March 14, 2008 (sent for review February 8, 2008)
Starvation of yeast cultures limited by auxotrophic requirements results in glucose wasting and failure to achieve prompt cell-cycle arrest when compared with starvation for basic natural nutrients like phosphate or sulfate. We measured the survival of yeast auxotrophs upon starvation for different nutrients and found substantial differences: When deprived of leucine or uracil, viability declined exponentially with a half-life of
