LAB/IN VITRO RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2016; 22: 4881-4886 DOI: 10.12659/MSM.898658
Inhibition of Cervical Cancer by Promoting IGFBP7 Expression Using Ellagic Acid from Pomegranate Peel
Received: 2016.03.22 Accepted: 2016.04.08 Published: 2016.12.12
Authors’ ABCDEFG Contribution: Hongjun Guo Study Design A CDE Dongya Zhang Data Collection B BF Qingrui Fu Statistical Analysis C Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
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Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China
Dongya Zhang, e-mail:
[email protected] Departmental sources
The aim of this study was to explore the mechanism by which cervical cancer is inhibited by promoting IGFBP7 expression using ellagic acid from pomegranate peel extract. HeLa cells were divided into 6 groups: control group (NC), blank control group (BL), and IGFBP7 overexpression group (IGFBP7), and 2.5 uM, 5. 0 uM, and 10.0 uM ellagic acid-treated groups. The cell proliferation ability was detected and the degree of invasion in the 6 groups was measured by Transwell assay. The expression levels of IGFBP7 and AKT/mTOR in the 6 groups of cells were detected by RT-PCR technique. Compared with NC and BL groups, The IGFBP7 gene expressions of the IGFPB7 and ellagic acid-treated groups were significantly increased (P
