1102
STOMACH
Inhibitory effects of Helicobacter pylori infection on murine autoimmune gastritis M Ohana, K Okazaki, C Oshima, K Kawasaki, T Fukui, H Tamaki, M Matsuura, M Asada, T Nishi, K Uchida, S Uose, H Nakase, M Iwano, Y Matsushima, H Hiai, T Chiba ............................................................................................................................. Gut 2003;52:1102–1110
See end of article for authors’ affiliations
.......................
Correspondence to: K Okazaki, Department of Gastroenterology and Endoscopic Medicine, Faculty of Medicine, Kyoto University, 54 Shogoin-Kawara-cho, Sakyo, Kyoto, 606-8507 Japan;
[email protected] Accepted for publication 3 March 2003
.......................
A
Background and aim: Long term Helicobacter pylori infection leads to atrophic gastritis but the relation between H pylori infection and autoimmune related atrophic gastritis (AIG) remains unclear. We studied the effects of H pylori infection on the pathophysiology of AIG in mice. Materials and methods: BALB/c nu/nu mice (n=40) with or without H pylori infection received splenocytes from neonatally thymectomised mice to induce AIG. Half of the mice were orally infected with H pylori prior to AIG induction. Histological findings, and local and systemic immune responses were serially evaluated. Results: Two and six months after transfer, parietal cells in uninfected mice were depleted while those in infected mice were well preserved. The degree of gland atrophy (p
