Jun 16, 2008 - (BMI 18.5â24.9) women, smoking decreased the risk of preeclampsia (for heavy smoking, light smoking, non- smoking, test for trend p ¼ 0.002 ...
American Journal of Epidemiology Published by the Johns Hopkins Bloomberg School of Public Health 2008.
Vol. 168, No. 4 DOI: 10.1093/aje/kwn140 Advance Access publication June 16, 2008
Original Contribution Interactions between Smoking and Weight in Pregnancies Complicated by Preeclampsia and Small-for-Gestational-Age Birth
Roberta B. Ness1, Jun Zhang2, Debra Bass1, and Mark A. Klebanoff2 1
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
2
Received for publication February 20, 2008; accepted for publication May 1, 2008.
Cigarette smoking protects against preeclampsia but increases the risk of small-for-gestational-age birth (SGA). Regarding body weight, the converse is true: obesity elevates rates of preeclampsia but reduces rates of SGA. The authors assessed the combined effects of smoking and weight among US women developing preeclampsia or SGA, studying 7,757 healthy, primigravid women with singleton pregnancies in 1959–1965. Smoking (never, light, heavy), stratified by prepregnancy body mass index (BMI (weight (kg)/height (m)2); underweight, overweight, obese), was examined in relation to preeclampsia and SGA. Among underweight (BMI
