Sep 15, 2008 - to be a transplacental carcinogen in mice and rats (23,26â29). The International Agency for Research on Cancer has classified. AZT as a group ...
Mutagenesis vol. 24 no. 2 pp. 133–141, 2009 Advance Access Publication 20 October 2008
doi:10.1093/mutage/gen059
Interference of cell cycle progression by zidovudine and lamivudine in NIH 3T3 cells
Jia-Long Fang*, Lynda J. McGarrity1 and Frederick A. Beland Division of Biochemical Toxicology and 1Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Zidovudine (3#-azido-3#-deoxythymidine; AZT) and lamivudine [(2)2#,3#-dideoxy-3#-thiacytidine; 3TC] are nucleoside reverse transcriptase inhibitors used to treat and prevent human immunodeficiency virus-1 infections. In short-term incubations (
