Investigating the influence of mtDNA and nuclear ... - Nature › publication › fulltext › Investigati... › publication › fulltext › Investigati...by NR Harvey · 2020 · Cited by 1 · Related articlesGenetics may influence exercise response in conjunction
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Investigating the influence of mtDNA and nuclear encoded mitochondrial variants on high intensity interval training outcomes N. R. Harvey 1,2, S. Voisin 3, R. A. Lea2, X. Yan 3, M. C. Benton 2, I. D. Papadimitriou M. Jacques3, L. M. Haupt 2, K. J. Ashton 1, N. Eynon 3,4 & L. R. Griffiths 2,4*
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Mitochondria supply intracellular energy requirements during exercise. Specific mitochondrial haplogroups and mitochondrial genetic variants have been associated with athletic performance, and exercise responses. However, these associations were discovered using underpowered, candidate gene approaches, and consequently have not been replicated. Here, we used whole-mitochondrial genome sequencing, in conjunction with high-throughput genotyping arrays, to discover novel genetic variants associated with exercise responses in the Gene SMART (Skeletal Muscle Adaptive Response to Training) cohort (n = 62 completed). We performed a Principal Component Analysis of cohort aerobic fitness measures to build composite traits and test for variants associated with exercise outcomes. None of the mitochondrial genetic variants but eight nuclear encoded variants in seven separate genes were found to be associated with exercise responses (FDR
