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Disclosure statement: L.B. has received honoraria from Roche, MSD,. Pfizer and BMS. B.K. has received honoraria from AbbVie, BMS, MSD,. Novartis, Pfizer ...
University College Cork, Cork, Ireland (E-mail: lemmy@ ucc.ie). Verhave, & Newman, 1990). Numerous stud- ies have examined the formation of equiva-.
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UNVEILED BY A NOVEL ELEVATED PLATFORM. TASK. William Suo1, XueFeng Ding1, Wei Peng2, Qiang Zhang1, 1Veterans Affairs. Medical Center, Kansas City, Missouri, United States; 2Veterans Affairs ... Contact e-mail: [email protected].
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ABSTRACT. There is controversy regarding the incidence and signifi- cance of hypothalamic-pituitary-adrenal (HPA) axis dysfunction in chronic fatigue ...
Diagnosis and Treatment of Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysfunction in Patients with Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) Kent Holtorf, MD
ABSTRACT. There is controversy regarding the incidence and significance of hypothalamic-pituitary-adrenal (HPA) axis dysfunction in chronic fatigue syndrome (CFS) and fibromyalgia (FM). Studies that utilize central acting stimulation tests, including corticotropin-releasing hormone (CRH), insulin stress testing (IST), d-fenfluramine, ipsapirone, interleukin-6 (IL-6) and metyrapone testing, have demonstrated that HPA axis dysfunction of central origin is present in a majority of these patients. However, ACTH stimulation tests and baseline cortisol testing lack the sensitivity to detect this central dysfunction and have resulted in controversy and confusion regarding the incidence of HPA axis dysfunction in these conditions and the appropriateness of treatment. While both CFS and FM patients are shown to have central HPA dysfunction, the dysfunction in CFS is at the pituitary-hypothalamic level while the dysfunction in FM is more related to dysfunction at the hypothalamic and supra-hypothalamic levels. Because treatment with low physiologic doses of cortisol (