Aug 25, 2013 - 3 Cancer Management and Research Department, Medical ... Before surgery, big ET-1 serum levels of all breast cancer patients were ...
Journal of Cancer Research & Therapy
NobleResearch
Hussein NA et al., J Cancer Res Ther 2013, 1(7):178–185 http://dx.doi.org/10.14312/2052-4994.2013-27
www.nobleresearch.org
Original research
Open Access
Evaluation of serum big endothelin-1 for the diagnosis and prediction of disease recurrence in breast cancer patients Hussein NA1,, Anwar MM2,, Elkerm Y3, Abozaid NA1 and Rashad MM1
Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt Experimental and clinical surgery Department, Medical Research Institute, Alexandria University, Alexandria, Egypt 3 Cancer Management and Research Department, Medical Research Institute, Alexandria University, Alexandria, Egypt 1 2
Abstract
Big endothelin-1 (big ET-1) is the biological precursor of endothelin-1 (ET-1) and it is known as an indicator for the degree of activation of endothelin system. Therefore, this study was designed to investigate the serum big ET-1 levels in newly diagnosed primary breast cancer patients; before surgery and after adjuvant therapy. In addition this study was also aimed at examining the correlation between big ET-1 and CA15.3, clinical and pathological criteria of breast cancer, as well as their status during the follow up period after adjuvant therapy. The study consisted of 40 females with newly diagnosed primary breast cancer treated at the Medical Research Institute hospital and 15 healthy females as a control group. Before surgery, big ET-1 serum levels of all breast cancer patients were significantly higher than those of the control group (p0.001). However, after both surgery and adjuvant therapy, big ET-1 was significantly decreased compared to its level before surgery (p
