International and American Associations for Dental Research can be found at: ..... Provenza DV (1988). Fundamentals of oral histology and embryology. 2nd ed.
Journal of Dental Research http://jdr.sagepub.com/
Effect of Age on Immunoglobulin Content and Volume of Human Labial Gland Saliva D.J. Smith, K. Joshipura, R. Kent and M.A. Taubman J DENT RES 1992 71: 1891 DOI: 10.1177/00220345920710120701 The online version of this article can be found at: http://jdr.sagepub.com/content/71/12/1891
Published by: http://www.sagepublications.com
On behalf of: International and American Associations for Dental Research
Additional services and information for Journal of Dental Research can be found at: Email Alerts: http://jdr.sagepub.com/cgi/alerts Subscriptions: http://jdr.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav Citations: http://jdr.sagepub.com/content/71/12/1891.refs.html
Downloaded from jdr.sagepub.com by guest on July 10, 2011 For personal use only. No other uses without permission.
Effect ofAge on Immunoglobulin Content and Volume of Human Labial Gland Saliva D.J. SMITH, K. JOSHIPURA', R. KENT', and M.A. TAUBMAN Departments ofImmunology and 'Biostatistics, Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115
Stimulated lower labial (LLGF) and parotid salivary volumes and IgG, IgA, and IgM concentrations were measured in 264 subjects Materials and methods. whose ages ranged from 17 to 76 years. A significant (p 90 years of age). Taken together, these observations suggest that the quality of mucosal immunity may become compromised with aging, despite apparently "normal" quantities of IgA.
Acknowledgments. The authors acknowledge the skillful technical assistance of Mary Ritchie and Pia Ali-Salaam for sample collection and Ig analysis, and the efficient scheduling of subjects by Peggy Resker. REFERENCES Baum BJ (1981). Evaluation of stimulated parotid salivary flow rate in different age groups. J Dent Res 60:1292-1296. Brandtzaeg P (1977). Immunohistochemical studies on various aspects of glandular immunoglobulin transport in man. Histochem J 9:553-572. Brandtzaeg P, Valnes K, Scott H, Rognum TO, Bjerke K, Baklien K (1985). The human gastrointestinal secretary immune system in health and disease. Scand J Gastroenterol 114:17-38. ChaunceyHH, Borkan GA, WaylerAH, FellerRP, Kapur KK(1981). Parotid fluid composition in healthy aging males. Adv Physiol Sci 28:323-328. Crawford JM, Taubman MA, Smith DJ (1975). Minor salivary glands as a major source of secretary immunoglobulin A in the human oral cavity. Science 190:1206-1209. Czerkinsky C, Quiding M, Nordstrom I, Ahlfors E, Friman W, Svennerholm A-M, et al. (1990). Lymphoid cell population dynamics and the mucosal immune response in humans. In: MacDonald TT, Challacombe SJ, Bland PW, Stokes CR, Heatley RV, Mowat AA, editors. Advances in mucosal immunology. Dordrecht (The Netherlands): Kluwer Academic Publishers, 326-331. Dawes C, Wood CM (1973). The composition of human lip mucous gland secretions. Arch Oral Biol 18:343-350. Drummond JR, Chisholm DM (1984). A qualitative and quantitative study of the ageing human labial salivary glands. Arch Oral Biol 29:151-155. Heft M, Baum BJ (1984). Unstimulated and stimulated parotid salivary gland flow rate in individuals ofdifferent ages. JDent Res 63:1182-1185. Kaaber S (1977). Sodium and potassium content in human palatine fluid secretion. Arch Oral Biol 22:529-535. Kawanishi H, Ajitsu S, Mirabella S (1990). Impaired humoral immune responses to mycobacterial antigen in aged murine gut-associated lymphoid tissues. Mech Ageing & Devel 54:143-161. Kawanishi H, Senda S, Ajitsu S (1989). Aging-associated intrinsic defects in IgAproduction by murine Peyer's patch B cells stimulated by autoreactive Peyer's patch T cell hybridoma-derived B cell stimulatory factors (BSF). Mech Ageing & Devel 49:61-78. Moro I, Umemura S, Crago SS, Mestecky J (1985). Immunohistological distribution of immunoglobulins, lactoferrin, and lysozyme in human minor salivary glands. J Oral Pathol 13:97-104.
Nair PNR, Schroeder HE (1983). Local immune response to repeated topical antigen application in the simian labial mucosa. Infect Immun 41:399409. Nair PNR, Simmerli I, Schroeder HE (1987). Minor salivary gland ductassociated lymphoid tissue (DALT) in monkeys changes with age. JDent Res 66:407-411. Niedermeier W, Huber M (1989). Quantitative untersuchung zur sekretionsleistungdergaumenspeicheldrusen. DtschZahnarztlZ44:3740. Pedersen W, Schubert M, Izutsu K, Mersai T, Truelove E (1985). Agedependent decreases in human submandibular gland flow rates as measured under resting and post-stimulation conditions. J Dent Res 64:822-825. Provenza DV (1988). Fundamentals of oral histology and embryology. 2nd ed. Philadelphia (PA): Lea & Febiger. Russell MW, Hammond D, Radl J, Haaijman JJ, Mestecky J (1985). Secretory IgA, and IgA2 responses to environmental antigens. Protides of Biological Fluids 32:77-80. Schmucker DL, Daniels CK, Wang RK, Smith K (1988). Mucosal immune response to cholera toxin in ageing rats. I. Antibody and antibodycontaining cell response. Immunol 64:691-695. Scott J (1980). Quantitative and qualitative observations on the histology of human labial salivary glands obtained post mortem. J Biol Buccale 8:178-200. Smith DJ, Ebersole JL, Taubman MA (1983). Local and systemic immune response in aged hamsters. Immunol 50:407-413. Smith DJ, King WF, Taubman MA (1990). Isotypic and antigenic specificity of salivary and serum antibody to indigenous oral streptococci (abstract). J Dent Res 69:139. Smith DJ, Taubman MA (1990). Effect of local deposition of antigen on salivary immune responses and reaccumulation of mutans streptococci. J Clin Immunol 10:273-281. Smith DJ, Taubman MA, Ali-Salaam P (1991). Immunoglobulin isotypes in human minor gland saliva. JDent Res 70:167-170. Smith DJ, Taubman MA, Ebersole JL (1987a). Ontogeny and senescence of salivary immunity. J Dent Res 66:451-456. Smith DJ, Taubman MA, King WF (1987b). Immunological features of minor salivary gland saliva. J Clin Immunol 7:449-455. Speirs RL (1984). Secretion of saliva by human lip mucous glands and parotid glands in response to gustatory stimuli and chewing. Arch Oral Biol 29:945-948. Syrjanen S (1984). Age-related changes in structure of labial minor salivary glands. Age and Ageing 13:159-165. Taylor LD, Daniels CK, Adler RR, Schmucker DL (1991). Is gastrointestinal mucosal immune responsiveness compromised in old primates? In: Tsuchiya M, Nagura H, Hibi T, Moro I, editors. Frontiers of mucosal immunology. Amsterdam (The Netherlands): Excerpta Medica, 287288. Waterhouse JP, Chisolm DM, Winter RB, Patel M, Yale RS (1973). Replacement of functional parenchymal cells by fat and connective tissue in human submandibular salivary glands. An age-related study. J Oral Pathol 2:16-27.
Downloaded from jdr.sagepub.com by guest on July 10, 2011 For personal use only. No other uses without permission.
