Journal of Pediatric Gastroenterology and Nutrition Publish Ahead of Print DOI: 10.1097/MPG.0000000000001623 Effect of synbiotic on the gut microbiota of caesarean delivered infants: a randomized, double-blind, multicenter study
Mei Chien Chua1, MD, Kaouther Ben-Amor2, PhD , Christophe Lay3, PhD, Anne Goh Eng Neo1,MD , Wen Chin Chiang1 , MD, Rajeshwar Rao1, MD, Charmaine Chew3, MSc, Surasith Chaithongwongwatthana4,5 ,MD, Nipon Khemapech4,5,MD, Jan Knol2 ,6, PhD, Voranush Chongsrisawat4,5, MD.
Affiliations: 1KK Women’s and children’s Hospital, Singapore; 2Danone Nutricia Research, Utrecht, The Netherlands; 3Danone Nutricia Research, Singapore; 4King Chulalongkorn Memorial Hospital; 5Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 6Wageningen University, Wageningen, The Netherlands
Correspondence address and reprint requests to: Mei Chien Chua, Department of Neonatology, KK Women’s and Children’s Hospital, 100 Bukit Timah Road, Singapore 229899,
[email protected], Tel: +65 6394-1228
Short Title: Synbiotic, gut microbiota and C-section
Conflict of Interest source of funding: Kaouther Ben-Amor, Christophe Lay, Charmaine Chew and Jan Knol are employees of Danone Nutricia Research. The other authors have no conflicts of interest relevant to this article to disclose. The study was funded and sponsored by Danone Nutricia Research, The Netherlands. The infant formulas investigated in this study were provided by Danone Nutricia Research, The Netherlands.
Trial registration: www.trialregister.nl, NTR Number: 2838
Manuscript: 2221 words Table, figure and supplemental digital content: 1 Table, 1 Figure, 2 supplementary Figures and 5 supplementary Tables.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal’s Web site (www.jpgn.org). Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
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Abstract We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of caesarean born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (p
