Kinetic, Equilibrium, and Spectroscopic Studies on Dealkylation ...

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Dec 17, 1985 - with acetylcholinesterase undergoes aging with a half-life of ..... in a blue-shift of the fluorescence maxima to 630 nm from the value of 662 nm ...
THEJOURNAL OF BIOLOGICAL CHEMISTRY The American Society of Biological Chemists, Inc.

Vol. 261, No. 23, Issue of August 15, pp. 10646-10652, 1986 Printed in U.S. A.

8r’ 1986 by

Kinetic, Equilibrium, and Spectroscopic Studies on Dealkylation (“Aging”) of Alkyl Organophosphonyl Acetylcholinesterase ELECTROSTATICCONTROLOFENZYMETOPOGRAPHY* (Received for publication,December 17,

1985)

Harvey Alan Berman and Mildred M. Decker From the Department of Biochemical Pharmacology,State University of New York at Buffalo, Buffalo,New York 14260

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OH The mechanism of dealkylation (“aging”) of 0 0 OH ?,OR t ,OR branched-alkyl organophosphonyl conjugates of aceCH3-P,0 CHyb

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