Jul 5, 2016 - suppresses tumorigenicity and .... tion, the culture media was changed to fresh media containing 8 μ g/mL of .... In vivotumorigenicity assay.
www.nature.com/scientificreports
OPEN
received: 03 September 2015 accepted: 20 June 2016 Published: 05 July 2016
Knockdown of Pentraxin 3 suppresses tumorigenicity and metastasis of human cervical cancer cells Tsung-Ho Ying1,2, Chien-Hsing Lee3,4, Hui-Ling Chiou5, Shun-Fa Yang6, Chu-Liang Lin7, Chia-Hung Hung7, Jen-Pi Tsai8,9 & Yi-Hsien Hsieh7,10,11 Pentraxin 3 (PTX3) as an inflammatory molecule has been shown to be involved in immune response, inflammation, and cancer. However, the effects of PTX3 on the biological features of cervical cancer cells in vitro and in vivo have not been delineated. Immunohistochemical staining showed that increased PTX3 expression was significantly associated with tumor grade (P
