Christopher Miller. âIn Vivo Safety Testing of Biosimilar Drugs ... Stephen Kirk. âDetection of IgG and IgM ... Step
KEY SESSIONS AT SOT MONDAY, MARCH 13 “The Effect of Caffeic Acid on Liver and Peripheral Blood Lymphocytes as Measured by the Alkaline Comet Assay” Carol Beevers 9:30 AM - 12:15 PM • Room 309 “Begin with the SEND in Mind: Learnings, Challenges and Opportunities” Megan Bausman 12:00 PM - 1:00 PM • Room 339
COVANCE SCIENTISTS ARE ADVANCING SCIENCE. To view our entire scientific body of work, visit the Covance Knowledge Library. Through this resource you’ll gain unique insights and learn about innovative approaches to industry solutions for Drug Development. COVANCE KNOWLEDGE LIBRARY www.covance.com/latest-thinking/explore-library.html Learn more about our drug development solutions at www.covance.com
Global Initiatives for Replacement, Refinement and Reduction in Animal Use within Toxicology Programs “Reducing the Use of Recovery Animals” Paul Baldrick 3:00 PM - 4:00 PM • Room 337
TUESDAY, MARCH 14 “New Life for Natural Killer Cell Assays Using Non-Radioactive Approaches” Aric Frantz 3:00 PM – 4:00 PM • Room: 337
Covance Inc., headquartered in Princeton, NJ, USA is the drug development business of Laboratory Corporation of America Holdings (LabCorp). COVANCE is a registered trademark and the marketing name for Covance Inc. and its subsidiaries around the world.
LEARN ABOUT THE LATEST EXPLORATION AND DISCOVERY Join us in Booth #2213 at the SOT 56th Annual Meeting and ToxExpo™ (SOT).
SOT 2017 POSTERS
MORE THOUGHT LEADERSHIP View these past posters online at www.covance.com/latest-thinking/explore-library.html
MONDAY, MARCH 13 – CC Exhibit Hall 1:15 PM – 4:30 PM “Ocular Tolerability of iPSC-Derived RPE Following Subretinal Administration in RNU Nude Rats” Peter Sonnentag • P325
TUESDAY, MARCH 14 – CC Exhibit Hall 9:30 AM – 12:45 PM “Pharmacokinetics of Morphine and Metabolites in Monkeys After IV and Oral Administration” Mingguang Li • P134 “Magnet Resonance Imaging and Computer Tomography During the Conduct of Regulatory Studies with Nonhuman Primates: Can Enhanced Imaging Secure Your Study?” Stephanie Grote-Wessels • P162 1:15 PM – 4:30 PM “Germ Cell Pig-a Assay: A Trans-Tissue Application of the In Vivo Gene Mutation Assay” Javed Bhalli • P623 “Use of Miniaturized Bacterial Mutagenicity Assays for Drug Candidate Screening and Impurity Evaluation” Ron Fiedler • P634
WEDNESDAY, MARCH 15 – CC Exhibit Hall 9:30 AM – 12:45 PM
“Correlation of the Pig-a Assay with Regulatory Genetic Toxicology Endpoints” Robin Neft “Detection of DNA Cross-Links in Rat Liver and Kidney in the In Vivo Alkaline Comet Assay” Carol Beevers “Emerging Biologics Development Methods: Free-Ranging Cynomolgus Monkeys Undergoing Continuous Intravenous Infusion with an Implanted Port Catheter System – A Method Transfer in Courtesy to the ‘Refinement’ in the 3Rs” Christopher Miller “In Vivo Safety Testing of Biosimilar Drugs – Recent Experiences” Paul Baldrick “Long-Term Intrathecal Bolus Administration Studies in Cynomolgus Monkeys: Expected Background Findings, Procedure-Related Observations and Recommended Procedures” Marc Niehoff “Diagnostic Tools to Enhance Long-Term Intrathecal Delivery Studies in Nonhuman Primates” Sven Korte “Development of a PD-1 Receptor Occupation Method in Cynomolgus Whole Blood” Stephen Kirk “Detection of IgG and IgM Responses to Hepatitis B Antigen in the Cynomolgus Monkey” Aric Frantz “A Sensitive Method for Measuring ECG and Haemodynamic Parameters” Fiona Watts
“Repeated Blood Sampling in Catheterised Rats: A 3R Approach Enabling Disconnection and Group Housing in an Infusion/Oral Crossover Study Design” Hans van Wijk • P620
“Nude Female Mice Catheterised with the Pinport-in-Tail Cuff System, Allowing Disconnection of Tether (Potential Group Housing) in Intermittent Infusion Studies for Up to 108 Days” Hans van Wijk
“Not a Small Molecule and Not a Biologic: Class Effects in Nonhuman Primate Studies with 2nd Generation Oligonucleotide-Based Therapeutics Targeting Neuronal Orphan Diseases” Florian Timo Ludwig • P624
“Toxicokinetic Analysis of Acetaminophen following Liquid Microsampling – Evaluations of Rat and Mouse Plasma and Serum and Impact of Collection Site” Stephen Ploch
THURSDAY, MARCH 16 – Hall A 8:30 AM – 11:45 AM “3Rs Improvement: Are Satellite Groups for Toxicokinetic Evaluation of Control Groups Necessary?” Julia Detert • P239
“Options for Enhanced Analysis of Spermatogenesis in the Nonhuman Primate Model” Gerhard Weinbauer “Impact of Social Housing on Time-Mated Rabbits in an Embryo-Fetal Development Study Design” Michael O’Hara “Analytical Validation for Peripheral Blood Immunophenotyping of Myeloid, T and B cell Populations in Cynomolgus Macaques” Amber Rowse, et al. “Oligohydramnios in Cynomolgus Macaques” Ann Rozner
“Validation of 6- and 24-Well Plate Bacterial Mutagenicity Assay” Satin Sawant “Effects of Sedation by Acepromazine on Routine Clinical Pathology Parameters and Intraocular Pressure in Rabbits” Jacqueline Miller “Predose Phase Echocardiography Assessments for Canine Toxicology Studies: Are Two Better Than One?” Terri Bartko, et al. “AlphaTRAK and ReliOn® Confirm Glucometers for Use in Nonclinical Laboratory Testing; Anticoagulant Use and Sample Site Analysis” Matthew Schroeder and Alexandra Chesney “Effects of Social Housing on Cannibalism in Mice and Rats” Heidi Hsieh “Enhanced Imaging Has Proven to be a Safety Net During the Conduct of Regulatory Studies with Nonhuman Primates: The Value of Hard Data Before Necropsy” Sven Korte, et al. “Overcoming Data Integration Challenges to Produce SEND Datasets” Megan Bausman “Feasibility of Capillary Microsampling for Toxicokinetic Profile Analysis in the Juvenile Rat from Postnatal Day (PND) 4 Onwards” Deborah Perks and Josephine Burnett “Ex Vivo Evaluation of Immune-Enhancement, in the Cynomolgus Monkey, in Response to In Vivo Exposure to Several Checkpoint Inhibitors” Stephen Kirk “Microsampling for Toxicokinetic Studies” Josephine Burnett “Hematology Hurdles – Infusion of Biologics in Cynomolgus Monkeys” Florian Timo Ludwig “In Vitro Alternatives: Evaluation and Recommendations for the Reconstructed 3D Skin Micronucleus Assay (RSMN Assay): 72-hour Protocol” Darren Kidd “Development of an In Vitro Method for the Generation of Nonhuman Primate Cytokines as an Aid to the Establishment of Cytokine Multiplex Assays Used in Support of Pre-Clinical Safety Assessment” Kirpal Hunjan
