The following biomarkers were analyzed: fasting glucose, HbA1c, fasting ... In
obese women hs-CRP, fasting insulin, leptin and leptin/adiponectin ratio levels ...
LEPTIN TO ADIPONECTIN RATIO IS AN INDEPENDENT PREDICTOR OF COMMON CAROTID ARTERY INTIMA-MEDIA THICKNESS IN OBESE SUBJECTS
RĂZVAN VASILESCU1, SILVI IFRIM1 and CONSTANTIN IONESCU-TÎRGOVIŞTE2 1- Clinical Hospital Colentina – Department of Diabetes, Nutrition and Metabolic Diseases, Stefan Cel Mare str.19-21, Bucharest, Romania,
[email protected] 2-National Institute of Diabetes, Nutrition and Metabolic Diseases “N.Paulescu”, Bucharest
Received December 12, 2010
Background: Obesity it is associated with insulin resistance, chronic mild inflammation, type 2 diabetes and vascular disease. Increased production of most adipokines is involved in the development of obesity-related vascular diseases. Adiponectin is an adipokine with insulin-sensitising and anti-atheroslcerotic effects. Plasma adiponectin levels are reduced in obese subjects and in patients with type 2 diabetes, metabolic syndrome and cardiovascular diseases. In the present study we evaluated the association of traditional cardiovascular risk factors, adipokines, inflammation and insulin resistance with intima-media thickness (CIMT) of the common carotid artery, marker of subclinical atherosclerosis. Methods: The study included 117 healthy subjects (64 men and 53 women), who were classified according to their body mass index (BMI) into three groups: lean (BMI
