Levamisole-associated neutropenia and autoimmune ... - Europe PMC
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Levamisole-associated neutropenia and autoimmune ... - Europe PMC
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Levamisole-associated neutropenia and autoimmune granulocytotoxins DREW', B. M. CARTER', D. S. NATHANSON2, AND P. I. TERASAKI1 From the 'Department of Medicine and Surgery, University of California, and the 2Department of Surgical Oncology, University of California, Los Angeles, California, USA
S.
I.
To investigate possible immune mechanisms responsible for levamisole-associated neutropenia we tested patients with bladder cancer on levamisole therapy. Autoimmune and complement-dependent granulocytotoxic antibodies were detected in 3 patients with levamisoleinduced neutropenia. The granulocytopenia appeared to be causally related to the presence of autoantibodies in that pretreatment serum or serum obtained after the restoration of neutrophil counts showed diminished or no granulocytotoxic reactivity. In addition, granulocytotoxins were found in 6 out of 20 (30 %) patients receiving levamisole compared to only 2 out of 28 (7.1 %) patients on no levamisole or placebo (P
