Life-long endurance running is associated with

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AGE (2014) 36:9665 DOI 10.1007/s11357-014-9665-9

Life-long endurance running is associated with reduced glycation and mechanical stress in connective tissue Christian Couppé & René B. Svensson & Jean-Francois Grosset & Vuokko Kovanen & Rie H. Nielsen & Morten R. Olsen & Jytte O. Larsen & Stephan F. E. Praet & Dorthe Skovgaard & Mette Hansen & Per Aagaard & Michael Kjaer & S. Peter Magnusson

Received: 20 November 2013 / Accepted: 18 June 2014 # American Aging Association 2014

Abstract Life-long regular endurance exercise is known to counteract the deterioration of cardiovascular and metabolic function and overall mortality. Yet it remains unknown if life-long regular endurance exercise can influence the connective tissue accumulation of advanced glycation endproducts (AGEs) that is associated with aging and lifestyle-related diseases. We C. Couppé : R. B. Svensson : R. H. Nielsen : M. R. Olsen : D. Skovgaard : M. Hansen : M. Kjaer : S. P. Magnusson Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Bldg. 8, Bispebjerg Bakke 23, DK-2400 Copenhagen, NV, Denmark e-mail: [email protected] C. Couppé (*) : S. P. Magnusson Department of Physical Therapy, Musculoskeletal Rehabilitation Research Unit, Bispebjerg Hospital, Copenhagen, Denmark e-mail: [email protected] J.