Instructor: Dan Cohn. Office hours: Thursday 1-3PM, 1000 TLSB (same time and
place as in Part 1). Course Web Sites. Syllabus, problem assignments, practice ...
LS4 Part 2, Fall 2013 Instructor: Dan Cohn Office hours: Thursday 1‐3PM, 1000 TLSB (same time and place as in Part 1) Course Web Sites. Syllabus, problem assignments, practice midterms, keys, powerpoints and office hours are posted at: https://www.mcdb.ucla.edu/Research/Jacobsen/LabWebSite/P_Classes.shtml. Other information and the course discussion forum are at https://ccle.ucla.edu/blocks/ucla_browseby/view.php?term=13F&type=course&subjarea=LIFE SCI. Podcasts of the lectures are at http://www2.oid.ucla.edu/webcasts/courses/2013‐ 2014/2013fall Quizzes – quiz questions can be based on all problems + reading Quiz 5, November 4‐8: complementation testing Quiz 6, November 12‐15: One gene makes one protein; The genetic code; Hardy‐Weinberg (due to the Veteran’s Day holiday, Monday sections will take this quiz on November 25) Quiz 7, November 18‐22: Population genetics, Positional cloning Only Monday discussion sections will meet (and take Quiz 6) the week of November 25‐29 Quiz 8, December 2‐6: Individual identification; Genomics; Transgenics, Knockout mice Final: Tuesday 12/10, 6:30‐9:30 pm
4th Edition Lecture
Day
Date
Topic
Reading
Problems
1
F
11/1
Complementation testing reveals that genes are distinct entities
Ch. 7 216‐ 224
Ch. 7 #18‐23, 25
2
M
11/4
One gene makes one protein
Ch. 7 224‐ 231
Ch. 7 #27, 28, 30; IG Biochemical Genetics #1‐3
3
W
11/6
The genetic code
Ch. 8 246‐ 256
Ch. 8 #1‐9, 15
4
F
11/8
Hardy‐Weinberg populations
Ch. 19 655‐ 660
Ch. 19 #2‐5, 7, 9, 10, 12, 14
M
11/11
Administrative holiday
5
W
11/13
Evolution alters allele distributions
Ch. 19 665‐ 674
Ch. 19 #20, 21; IG Population Genetics 1‐5
6
F
11/15
Positional cloning in humans
Posted PDF Ch. 11 #20‐23, 25, 27; IG Molecular Markers #1‐3, 5
7
M
11/18
Individual identification
Ch. 11 370‐ Ch. 11 #1‐5, 12, 13, 17; IG Molecular Markers #6 381
8
W
11/20
Gene identification in the genomic era
Bamshad et al. Nature Reviews Genetics 12:745‐755, 2011
9
F
11/22
Transgenic animals
Posted PDF
Ch. 11 #26
10
M
11/25
Gene replacement in mice
Ch. 18 620‐ 625
Ch. 18 #12, 13
W
11/27
No Lecture
F
11/29
Happy Thanksgiving!
11
M
12/2
Model organisms and mutagenesis screens
Hafter et al. Development 123:1‐36, 1996
12
W
12/4
Rock et al. Nature Genetics 40:999‐ 1003, 2008
F
12/6
Human genetics from disease to treatment Problem solving clinics/TAs
Quiz 5 – Next week
Quiz 6 – 11/12‐15
Quiz 7 – 11/18‐22
Quiz 8 – 12/2‐6
