Oncotarget, Vol. 5, No. 11
www.impactjournals.com/oncotarget/
MACC1 promotes carcinogenesis of colorectal cancer via β-catenin signaling pathway Tiantian Zhen1,*, Sujuan Dai1,*, Hui Li1,*, Yang Yang1,*, Lili Kang1, Huijuan Shi1, Fenfen Zhang1, Dongjie Yang2, Shirong Cai2, Yulong He2, Yingjie Liang1, Anjia Han1 1
Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
2
Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
*
These authors contributed equally to this work
Correspondence to: Anjia Han, email:
[email protected] Keywords: MACC1, β-catenin, colorectal cancer, carcinogenesis Received: February 7, 2014
Accepted: May 18, 2014
Published: May 20, 2014
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ABSTRACT Here we confirmed that metastasis-associated in colon cancer 1 (MACC1) and β-catenin expression were higher in colorectal cancer (CRC) cells and tissues than those in normal colonic epithelial cell line and adjacent non-tumour colorectal mucosa (ANM) tissues, respectively. MACC1 expression was significantly related to histological differentiation (p
