MAGIC Study: Aims, Design and Methods using SystemCHANGE⢠to ...
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MAGIC Study: Aims, Design and Methods using SystemCHANGE⢠to ...
Received: 19 April 2016; Accepted: 24 June 2016 ... medications is the leading predictor of poor outcomes, including rejection, kidney loss, and death.
Russell et al. BMC Nephrology (2016) 17:84 DOI 10.1186/s12882-016-0285-8
STUDY PROTOCOL
Open Access
MAGIC Study: Aims, Design and Methods using SystemCHANGE™ to Improve Immunosuppressive Medication Adherence in Adult Kidney Transplant Recipients Cynthia L. Russell1*, Shirley Moore2, Donna Hathaway3, An-Lin Cheng1, Guoqing Chen4 and Kathy Goggin5
Abstract Background: Among adult kidney transplant recipients, non-adherence to immunosuppressive medications is the leading predictor of poor outcomes, including rejection, kidney loss, and death. An alarming one-third of kidney transplant patients experience medication non-adherence even though the problem is preventable. Existing adherence interventions have proven marginally effective for those with acute and chronic illnesses and ineffective for adult kidney transplant recipients. Our purpose is to describe the design and methods of the MAGIC (Medication Adherence Given Individual SystemCHANGE™) trial Methods/Design: We report the design of a randomized controlled trial with an attention-control group to test an innovative 6-month SystemCHANGE™ intervention designed to enhance immunosuppressive medication adherence in adult non-adherent kidney transplant recipients from two transplant centers. Grounded in the Socio-Ecological Model, SystemCHANGE™ seeks to systematically improve medication adherence behaviors by identifying and shaping routines, involving supportive others in routines, and using medication taking feedback through small patient-led experiments to change and maintain behavior. After a 3-month screening phase of 190 eligible adult kidney transplant recipients, those who are
