Sub-temporal amygdalohippocampectomy resections were most similar to the 'ideal' hippocampus resection. Conclusion: As this method allows the systematic ...
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Abstracts / Journal of the Neurological Sciences 381 (2017) 561–756
Background: Rheumatoid arthritis (RA) is a severe systemic disease which leads besides of points and organs to the defeat of central nervous system Objective: We aimed to study cognitive impairments, its relationship with duration of disease and age of patients with rheumatoid arthritis Patients and Methods/Material and Methods: The Clinical research was carried out in the department of rheumatology of the first clinic of Tashkent Medical Academy. We studied 50 patients with RA aged 18-65 years (mean age 48 ± 1,6 years), of them 36 women and 14 men, 71.1% and 28.9% respectively. Cognitive functions were tested using the Mini-Mental State Examination (MMSE) Results: Patients aged 30-50 years were the most common of all patients we studied. The duration of the disease lasts from 1.5 months to 25 years. The average duration of the disease is 10.5 years. We studied cognitive function of patients by MMSE scale. The mean MMSE scale was 25,9. Mild cognitive disorders were the highest in 21 patients (42%), whereas in 12 patients (24%) we found the mild dementia, by the way in 17 patients (34%) cognitive deficiency wasn’t found. Depending on the duration of RA (b2 years - N 20 years), MMSE scale decreased from 28.3 to 25 (P b0,001). Depending on the age of the RA (b30 - N 65) MMSE scale decreased from 28.4 to 26 (P b0,001) Conclusion: We concluded that cognitive deficiency is common in patients with RA. The severity of cognitive impairment is higher than the RA is longer and the age of the patients greater doi:10.1016/j.jns.2017.08.1914
1885 WCN17-1857 SHIFT 5 - EPILEPSY Mapping whole brain connectivity changes associated with surgical technique in temporal lobe epilepsy N. Busby, A. Halai, M. Lambon Ralph. University of Manchester, Neuroscience and Aphasia Unit, Manchester, United Kingdom Background: If anti-epileptic drugs fail to control focal seizures in temporal lobe epilepsy, surgical removal of regions of the temporal lobe may be necessary. Complete or partial unilateral resection of the temporal lobe (en-bloc anterior temporal lobectomy) is considered the gold standard technique to alleviate seizures, but advanced
surgical techniques try to lessen deficits through smaller resections or by going under (sub-temporal), over (trans-Sylvian) or through the temporal lobe (middle-temporal). No systematic studies have shown the effect of this surgery on white matter connectivity. Objective: To perform pseudo-neurosurgery on Human Connectome data. Patients and Methods/Material and Methods: Nine masks were drawn in a 3x3 design to represent resections measuring 2cm, 4cm and 6cm from the temporal pole, encompassing one or more temporal gyri.
Abstracts / Journal of the Neurological Sciences 381 (2017) 561–756
By systematically removing tissue associated with each surgical method in the same healthy controls, the extent of whole-brain connectivity changes can be observed using Anatomical Connectivity Mapping (ACM). Results: Hippocampus and amygdala only resections were used as an ‘ideal’ baseline and were associated with connectivity change within the cingulum, arcuate and inferior longitudinal fasciculus (ILF). For enbloc resections, as distance from the temporal pole increased, connectivity changes were evident within the arcuate, ILF and inferior fronto-occipital fasciculus. Increasing height of resections up the temporal lobe gyri increased connectivity changes within the uncinate, suggesting both resection height and length affect connectivity postsurgery. Sub-temporal amygdalohippocampectomy resections were most similar to the ‘ideal’ hippocampus resection. Conclusion: As this method allows the systematic assessment of connectivity change associated with surgical technique; ACM may be a useful tool in neurosurgical planning.
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1887 WCN17-2540 SHIFT 5 - EPILEPSY Compensatory semantic processing after resection of the anterior temporal lobe in epilepsy surgery M. Otaa, A. Shimotakeb, R. Matsumotoa, M. Sakamotoa, M. Daifua, T. Nakaec, T. Kikuchic, K. Yoshidac, T. Kuniedad, S. Miyamotoc, R. Takahashia, L.R. Matthewe, A. Ikedab. aKyoto University Graduate School of Medicine, Department of neurology, Kyoto, Japan; bKyoto University Graduate School of Medicine, Department of Epilepsy-Movement Disorders and Physiology, Kyoto, Japan; cKyoto University Graduate School of Medicine, Department of neurosurgery, Kyoto, Japan; dEhime University Graduate School of Medicine, Department of neurosurgery, Matsuyama, Japan; eUniversity of Manchester, Sch. of Psychological Sci.Neurosci. And Aphasia Res. Unit, Manchester, United Kingdom
doi:10.1016/j.jns.2017.08.1915
Background: According to semantic dementia study, the anterior temporal lobe (ATL) plays a major role in role in semantic processing. In the epilepsy field, the left ventral part of the ATL (vATL) is known as the basal temporal language area (BTLA). The functional compensational mechanism for ATL resection remains elusive.
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Objective: We aimed to elucidate the role of vATL for the semantic processing and compensational course after ATL resection.
WCN17-0999 SHIFT 5 - EPILEPSY Usefulness of including cognitive tasks as activation method in standard EEG: A preliminary Japanese experience Y. Omotea, M. Fujiokab, H. Ikedab, D. Hirozawab, T. Oboshib, K. Imaib, K. Teradab, Y. Inoueb, P. Wolfc. aOkayama Medical Center, Neurology, Okayama, Japan; bNHO Shizuoka Institute of Epilepsy and Neurological Disorders, epilepsy, Shizuoka, Japan; cDanish Epilepsy Centre Filadelfia, epilepsy, Dianalund, Denmark Background: Cognitive tasks are known to evoke epileptiform discharges (ED) during electroencephalography (EEG). Objective: The aim of this study was to evaluate the usefulness of cognitive task EEG as routine examination. We show here the preliminary Japanese results of an international prospective multicenter study. Patients and Methods/Material and Methods: Thirty-two patients with idiopathic generalized epilepsy (IGE) including 22 juvenile myoclonic epilepsy (JME) and 5 juvenile absence epilepsy (JAE) underwent video-EEG monitoring with cognitive tasks such as speaking, spatial construction, attention, writing and calculation. ED frequencies during these tasks for 3 minutes each were compared with those during 15 minutes baseline with closed eyes, 5 minutes hyperventilation (HV), 5 minutes eyes open, opening and closing eyes, and photic stimulation (PS). Induction of ED 2 times more than baseline was defined as significant. Results: Frequency of baseline ED was 0.36±0.78/3min(mean± SD) in all patients, 0.08±0.21/3min in JME, 1.36±1.61/3min in JAE and 0.56±0.43/3min in other IGE. Seven absences were observed in 2 JAE in baseline. ED were significantly induced by HV in 11 patients (34.3%), eyes open in 3 (9.3%), PS in 7 (21.8%) and cognitive tasks in 5 (15.6%: all JME). Clinical seizures were evoked in 2 JME: jerks during speaking and absences during HV and eyes open, and 9 absences in 2 JAE during HV and PS. There were no ED during the entire recordings in 12 JME. Conclusion: Cognitive task EEG was useful for detecting ED or clinical seizures especially in JME. doi:10.1016/j.jns.2017.08.1916
Patients and Methods/Material and Methods: Subjects are 8 language-dominant patients with intractable temporal lobe epilepsy (TLE), who had an epilepsy surgery. We applied semantic tasks (synonym judgment, picture naming, association, and spoken-word picture matching) pre- and post-operatively (1 week, 1 month, 6 months and 1 year after surgery) by assessing accuracy rate, and number size judgement task as a control task. We gathered 22 elderly healthy volunteers for a normal control data. Results: Preoperatively, 3 patients showed lower accuracy than the normal volunteers' in semantic tasks especially synonym judgment and naming tasks. More than 4 patientshad decreased accuracy in the semantic tasks, mainly naming task (b70% in 3 patients) postoperative 1 week, but mostly recovered within 6 months. Conclusion: Patients with the language-dominant ATL resection showed impaired semantic function immediately after surgery, which generally recovered within 6 months. The language-dominant vATL is one of the important regions for semantic processing. Consective semantic network evaluation before and after surgery warrants compensatory mechanism for the deficits observed in dominant ATL resection.
doi:10.1016/j.jns.2017.08.1917
1888 WCN17-3230 SHIFT 5 - EPILEPSY Electro-clinical features of language-induced seizures M. Otania, R. Matsumotoa, N. Ueharab, T. Fumuroc, A. Shimotaked, M. Matsuhashie, A. Demuraf, M. Kinoshitab, R. Takahashia, A. Ikedad. a Kyoto University Graduate School of Medicine, neurology, Kyoto, Japan; b Utano National Hospital-National Hospital Organization, neurology, Kyoto, Japan; cSchool of Health Sciences at Fukuoka-International University of Health and Welfare, medical technology and sciences, Fukuoka, Japan; dKyoto University Graduate School of Medicine, Epilepsy-Movement disorder and physiology, Kyoto, Japan; eKyoto University Graduate School of Medicine, Human Brain Research Center, Kyoto, Japan; fUtano National Hospital-National Hospital Organization, Clinical Laboratory, Kyoto, Japan
