RESEARCH ARTICLE
Maternal Whole Blood Gene Expression at 18 and 28 Weeks of Gestation Associated with Spontaneous Preterm Birth in Asymptomatic Women a11111
OPEN ACCESS Citation: Heng YJ, Pennell CE, McDonald SW, Vinturache AE, Xu J, Lee MWF, et al. (2016) Maternal Whole Blood Gene Expression at 18 and 28 Weeks of Gestation Associated with Spontaneous Preterm Birth in Asymptomatic Women. PLoS ONE 11(6): e0155191. doi:10.1371/journal.pone.0155191
Yujing J. Heng1,2*, Craig E. Pennell3, Sheila W. McDonald4, Angela E. Vinturache4,5, Jingxiong Xu1,6, Mary W. F. Lee1, Laurent Briollais1,6, Andrew W. Lyon7, Donna M. Slater4,5, Alan D. Bocking1, Lawrence de Koning4,8,9, David M. Olson10, Siobhan M. Dolan11, Suzanne C. Tough4,9, Stephen J. Lye1 1 Departments of Obstetrics & Gynaecology and Physiology, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, 2 Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, United States of America, 3 School of Women's and Infants' Health, The University of Western Australia, Crawley, WA, Australia, 4 Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 5 Departments of Obstetrics & Gynaecology and Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, AB, Canada, 6 Dalla Lana School of Public Health, University of Toronto, ON, Canada, 7 Department of Pathology and Lab Medicine, University of Saskatchewan, St Paul’s Hospital, Saskatoon Health Region, Saskatoon, SK, Canada, 8 Calgary Laboratory Services, Calgary, AB, Canada, 9 Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 10 Departments of Obstetrics & Gynecology, Physiology and Pediatrics, University of Alberta, Edmonton, AB, Canada, 11 Department of Obstetrics & Gynecology and Women's Health (Reproductive Genetics), Albert Einstein College of Medicine, Bronx, NY, United States of America *
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Editor: Dongmei Li, University of Rochester, UNITED STATES Received: February 22, 2016 Accepted: April 25, 2016 Published: June 22, 2016 Copyright: © 2016 Heng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Data were deposited into the National Center for Biotechnology Information Gene Expression Omnibus (accession number: GSE59491). Funding: This work was supported by Alberta Innovates Health Solutions (Interdisciplinary Team Grant #200700595) and Global Alliance to Prevent Prematurity and Stillbirth (GAPPS award #12006). YJH was supported by a Canadian Institutes of Health Fellowship. Calgary Laboratory Services provided support in the form of salary for LdK. The funders had no role in study design, data collection
Abstract The heterogeneity of spontaneous preterm birth (SPTB) requires an interdisciplinary approach to determine potential predictive risk factors of early delivery. The aim of this study was to investigate maternal whole blood gene expression profiles associated with spontaneous preterm birth (SPTB,
