Measurement and clinical implications of choroidal ... - Semantic Scholar

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enhanced depth imaging (EDI), has been shown to be capable of visualizing the full thickness of the choroid(8). Changes in choroidal thickness have previously ...
Original Article

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease Determinação da espessura da coróide suas implicações clínicas em pacientes com doença inflamatória intestinal Ibrahim Koral Onal1, Erdem Yuksel2, Kemal Bayrakceken2, Muhammed Mustafa Demir1, Emine Esra Karaca2, Mehmet Ibis1, Nasser Alizadeh1, Zeynep Gok Sargin1, Ahmet Murat Hondur2, Mehmet Arhan1

ABSTRACT

RESUMO

Purpose: Ocular inflammation is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and may parallel disease activity. In this study, we evaluated the utility of a choroidal thickness measurement in assessing IBD activity. Methods: A total of 62 eyes of 31 patients with IBD [Crohn’s disease (CD), n=10 and ulcerative colitis (UC), n=21] and 104 eyes of 52 healthy blood donors were included in this study. Choroidal thickness was measured using enhanced depth imaging optical coherence tomography. The Crohn’s disease activity index (CDAI) and the modified Truelove Witts score were used to assess disease activity in CD and UC, respectively. Results: No significant differences in mean subfoveal, nasal 3000 µm, or temporal 3000 µm choroidal thickness measurements (P>0.05 for all) were observed between IBD patients and healthy controls. Age, smoking, CD site of involvement (ileal and ileocolonic involvement), CDAI, CD activity, and UC endoscopic activity index were all found to be significantly correlated with choroidal thickness by univariate analysis (P