Measuring multiple cognitive domains optimizes prediction of future ...

P486

Poster Presentations: P3

hypometabolism becomes significant in mild cognitive impairment (MCI) stage. The concept of early and late MCI was recently introduced by Alzheimer’s Disease Neuroimaging Initiative (ADNI)-Go and ADNI-2 based on severity of delayed recall impairment in logical memory. However, the state of brain amyloid load and metabolism dysfunction remains unknown in early and late stage of MCI. The present study aims to examine the brain amyloid burden and metabolism among cognitively normal (CN), early MCI (EMCI), late MCI (LMCI) and mild AD. Methods: In the present study, 354 participants, including CN (n¼109), EMCI (n¼157), LMCI (n¼39) and AD (n¼49), were included between September 2009 and November 2011 through ADNI-GO and ADNI-2. Brain amyloid load and metabolism were estimated by [18F]AV45 and fludeoxyglucose (FDG) PET, respectively. Global cortical uptake ratio of [18F]AV45 and [18F]FDG were calculated by combining the prefrontal, orbito-frontal, parietal, temporal, anterior cingulate and posterior cingulate/precuneus ratio values relative to cerebellar grey matter and pons, respectively. Global group differences were computed using ANOVA and voxel-based group differences were estimated using statistic parametric mapping (SPM). Results: Demographic data, global uptake ratio of [18F]AV45 and [18F]FDG were shown in Table 1. EMCI patients showed higher global [18F]AV45 retention compared to CN and lower uptake in contrast to LMCI. SPM detected higher [18F]AV45 uptake in EMCI compared to CN mainly in bilateral medial prefrontal cortices, dorsal lateral prefrontal cortices, posterior cingulate cortex and precuneus; LMCI showed significantly higher [18F] AV45 retention than EMCI remarkably in the bilateral superior temporal cortex, inferior parietal cortices, as well as dorsal lateral prefrontal cortex. Regarding to [18F]FDG, a small but significant cluster with lower metabolism was observed in left middle temporal cortex in EMCI in contrast to NC; Compared to EMCI, LMCI showed significantly lower metabolism in bilateral precuneus, hippocampus, entorhinal cortex, and inferior parietal cortex. Conclusions: The present results indicate clear amyloid deposition in EMCI

and hypometabolism in LMCI stage. These results suggest a role for antiamyloid interventions in EMCI aiming to delay or halt the amyloid deposition. P3-097

OBJECTIVE AND SUBJECTIVE OLFACTORY IMPAIRMENT IN NONAMNESTIC MILD COGNITIVE IMPAIRMENT

Martin Vyhnalek1, Hana Magerova2, Alexandra Kadlecova3, Tomas Nikolai4, Jan Laczo5, Eva Literakova3, Yonas Geda6, Jakub Hort7, 1 Memory Disorders Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic; 2Charles University, 2nd Medical School and University Hospital Motol, Prague, Czech Republic; 3Memory Disorders Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic; 4 Memory Disorders Clinic, Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic; 5Charles University in Prague, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic; 6Mayo Clinic College of Medicine, Rochester, Minnesota, United States; 7International Research Center, Brno, Czech Republic. Background: The olfactory identification impairment in amnestic mild cognitive impairment (aMCI) which precedes mainly Alzheimer disease (AD) is well known and is considered to be caused by AD pathology. The degree of olfactory impairment in nonamnestic MCI (naMCI), which converts mainly to non-Alzheimer’s types of dementia, is less known. There is little information whether the olfactory deficit in MCI is perceived by patients. The aim of this study was to examine the degree of objective and subjective olfactory dysfunction in naMCI and to compare it to aMCI. Methods: 89 patients with aMCI and 29 patients with naMCI according to Peterson’s criteria and 49 age-matched healthy controls underwent a multiple choice olfactory identification test with 18 different odors developed in our memory clinic and rated their subjective olfaction on visual analogue scale. Results: Both a MCI and naMCI patients showed considerable impairment in olfactory identification test compared to controls (P0.5). Conclusions: The olfactory identification impairment in naMCI is indistinguishable from aMCI. NaMCI often converts to frontotemporal lobar degeneration, dementia with Lewy body or vascular dementia and the olfactory deficit found in this study could be explained by the recently demonstrated olfactory impairment in these dementia subtypes. The impairment of olfaction is not subjectively perceived by the patients. P3-098

MEASURING MULTIPLE COGNITIVE DOMAINS OPTIMIZES PREDICTION OF FUTURE DECLINE IN PERSONS WITH MILD COGNITIVE IMPAIRMENT

Sylvie Belleville1, Emilie Lepage1, Marie-Jeanne Kergoat1, Serge Gauthier2, 1Research Center, Institut Universitaire de Geriatrie de Table 1 Demographic data, global uptake ratio of [18F]AV45 and [18F]FDG for all groups

Gender (M/F) Age (years) Education (years) MMSE CDR ADAS-cog Delayed recall of logical memory Global uptake ratio of AV45 Global uptake ratio of FDG

CN (n¼109)

EMCI (n¼157)

LMCI (n¼39)

AD (n¼49)

P value

53/56 78.8 6 5.9 16.4 6 2.8 29.1 6 1.2 060 6.2 6 4.2 14.0 6 3.7 1.28 6 0.25 1.29 6 0.13

90/67 73.1 6 7.9a 16.0 6 2.7 28.3 6 1.5a 0.5 6 0.1a 7.9 6 3.4a 9.3 6 2.1a 1.40 6 0.33a 1.31 6 0.15

24/15 76.2 6 9.2d 16.4 6 3.2 27.1 6 2.2 a,c 0.5 6 0.1a 12.5 6 5.7 a,c 3.5 6 2.8 a,c 1.56 6 0.36 a,c 1.22 6 0.15b,c

32/18 75.6 6 7.8d 16.7 6 2.8 21.4 6 4.7 a,c,e 1.0 6 0.4 a,c,e 21.8 6 10.3 a,c,e 1.5 6 2.6 a,c,e 1.62 6 0.38 a,c 1.14 6 0.15 a,c,e

0.231