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Vol. 41, No. 3, March 1997
BIOCHEMISTRYand MOLECULAR BIOLOGY INTERNATIONAL Pages597-607
METABOLIC FATE AND EFFECTS OF SATURATED AND UNSATURATED FATTY ACIDS IN HEP2 HUMAN LARYNX TUMOR CELLS Alison Colquhoun ~ and Rui Curl, Department of Physiology and Biophysics, Institute of Biomedical Sciences l, University of S~o Paulo, Brazil Received December 18, 1996
Previous studies have reported the presence of carnitine palmitoyltransferase 1 and II in tumor cells and the inhibitory effects of fatty acids on cell proliferation. The present work considered the metabolic fate of [14C] or [3HI-labeled fatty acids and their effects on cellular metabolism in Hep2 human larynx tumor cells.The rate of uptake of acetate was 45% of that of myristate, paimitate, oleate, iinoleate and arachidonate. However, acetate was rapidly metabolized within the cell as seen by its low rate of accumulation as non-esterified fatty acid,
