Supplementary Materials: Metabolomics Biomarkers for Detection of Colorectal Neoplasms: A Systematic Review Vanessa Erben, Megha Bhardwaj, Petra Schrotz-King and Hermann Brenner Figure S1. QUADAS Overview.
Note: red bar, proportion with high risk; green bar, proportion with low risk; yellow bar, proportion with unclear risk.
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Table S1. Performance characteristics of single metabolites and metabolomic panels of potential biomarkers with additional outcomes. First author, Year
Outcomes
Am A/ Pep
Metabolites FA CH
Others
Sn
Sp
Diagnostic performance AUC - No AUC with validation validation SS CV BS EV
p-value
Serum Guo, 2017 [24] Uchiyama, 2017 [23] Farshidfar, 2016 [14] Zhang, 2016 [26] F. Li, 2013 [29] Nishiumi, 2012 [35] Plasma Nishiumi et al., 2017 [39] S. Li, 2013 [43]
Miyagi, 2011 [44]
0 0 0 2 0
5 2 1 C7 2 4
0 0 0 1 0
0 0 0 9 0
73.1 81.3 88.0 n.a. 84.6
87.1 86.5 85.0 n.a. 89.8
0.85 0.90 0.92
0 3
10 0
0 1
0 0
98.1 82.8
100.0 n.a.
0.99
Stage 0 Stage I Stage II AP Stage 0 Stage I Stage II Stage III Stage IV
3 3 3 0 10 10 10 10 10
3 3 3 4 0 0 0 0 0
2 2 2 0 0 0 0 0 0
0 0 0 0 0 0 0 0 0
100.0 97.5 100.0 89.0 n.a.
100.0 91.3 91.7 80.0 n.a.
n.a.
CRC vs. Cn + BCD CRC/large P vs. small + no polyps Stage 0 Stage I Stage II Stage III Stage IV
