Metabolomics Biomarkers for Detection of Colorectal Neoplasms - MDPI

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10. 0. 0. 98.1. 100.0. 0.99.
Cancers 2018, 10, 246

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Supplementary Materials: Metabolomics Biomarkers for Detection of Colorectal Neoplasms: A Systematic Review Vanessa Erben, Megha Bhardwaj, Petra Schrotz-King and Hermann Brenner Figure S1. QUADAS Overview.

Note: red bar, proportion with high risk; green bar, proportion with low risk; yellow bar, proportion with unclear risk.

Cancers 2018, 10, 246

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Table S1. Performance characteristics of single metabolites and metabolomic panels of potential biomarkers with additional outcomes. First author, Year

Outcomes

Am A/ Pep

Metabolites FA CH

Others

Sn

Sp

Diagnostic performance AUC - No AUC with validation validation SS CV BS EV

p-value

Serum Guo, 2017 [24] Uchiyama, 2017 [23] Farshidfar, 2016 [14] Zhang, 2016 [26] F. Li, 2013 [29] Nishiumi, 2012 [35] Plasma Nishiumi et al., 2017 [39] S. Li, 2013 [43]

Miyagi, 2011 [44]

0 0 0 2 0

5 2 1 C7 2 4

0 0 0 1 0

0 0 0 9 0

73.1 81.3 88.0 n.a. 84.6

87.1 86.5 85.0 n.a. 89.8

0.85 0.90 0.92

0 3

10 0

0 1

0 0

98.1 82.8

100.0 n.a.

0.99

Stage 0 Stage I Stage II AP Stage 0 Stage I Stage II Stage III Stage IV

3 3 3 0 10 10 10 10 10

3 3 3 4 0 0 0 0 0

2 2 2 0 0 0 0 0 0

0 0 0 0 0 0 0 0 0

100.0 97.5 100.0 89.0 n.a.

100.0 91.3 91.7 80.0 n.a.

n.a.

CRC vs. Cn + BCD CRC/large P vs. small + no polyps Stage 0 Stage I Stage II Stage III Stage IV

2

0

0

0

n.a.

n.a.

0

1

0

0

88.0

53.0

0.70