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Supplementary material. Search strategies MEDLINE, DARE, HTA, NHS (Ovid) 1. (metastatic renal cell carcinoma).mp 2. (metastatic adj2 renal cell carcinoma).mp 3. (clear-cell metastatic renal cell carcinoma).mp 4. exp carcinoma, renal cell 5. (clear cell renal carcinoma).mp 6. (kidney adj2 neoplasm*).mp 7. (kidney adj2 carcinoma).mp 8. 1 OR 2 OR 3 OR 4 OR 5 OR 6 OR 7 9. (cytoreductive nephrectomy).mp 10. (cytoreductive adj2 nephrectomy).mp 11. Cytoreduct*.mp 12. 9 OR 10 OR 11 13. randomized controlled trial.pt 14. controlled clinical trial.pt 15. randomized.ab 16. placebo.ab 17. randomly.ab 18. trial.ab 19. (clinical adj2 trial).mp. 20. (randomi*ed adj2 controlled adj2 trial).mp. 21. exp double-blind method 22. exp cohort studies 23. cohort*.mp 24. exp case-control studies 25. (case-control stud*).mp 26. (Quasi-Experimental Stud*).mp 27. Non-randomized controlled trials as topic 28. 13 OR 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22 OR 23 OR 24 OR 25 OR 26 OR 27 29. 8 AND 12 AND 28 Embase 1. ’kidney carcinoma’/exp 2. (kidney next/2 neoplasm*):ti,ab 3. (kidney next/2 carcinoma):ti,ab 4. “metastatic renal cell carcinoma”:ti,ab 5. (metastatic next/2 “renal cell carcinoma”):ti,ab 6. “clear-cell metastatic renal cell carcinoma”:ti,ab 7. “clear cell renal carcinoma”:ti,ab 8. (“clear cell” next/2 “renal carcinoma”):ti,ab 9. 1 OR 2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8 10. ‘cytoreductive surgery’/exp 11. (cytoreductive next/2 nephrectomy):ti,ab 12. cytoreduct*:ti,ab 13. 10 OR 11 OR 12 14. 'randomized controlled trial'/exp 15. (randomi*ed NEXT/2 controlled NEXT/2 trial):ti,ab 16. 'clinical trial'/exp 17. (clinical NEXT/2 trial):ti,ab 18. 'double blind procedure'/exp 19. 'cohort analysis':ti,ab 20. 'cohort analysis'/exp 21. 'case control study'/exp 22. 'case control study':ti,ab 23. 'quasi experimental study'/exp 24. 'quasi experimental study':ti,ab 25. 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22 OR 23 OR 24 26. 9 AND 13 AND 25
Central (Ovid) 1. (metastatic renal cell carcinoma).mp 2. (metastatic adj2 renal cell carcinoma).mp 3. (clear-cell metastatic renal cell carcinoma).mp 4. exp carcinoma, renal cell 5. (clear cell renal carcinoma).mp 6. (kidney adj2 neoplasm*).mp 7. (kidney adj2 carcinoma).mp 8. 1 OR 2 OR 3 OR 4 OR 5 OR 6 OR 7 9. (cytoreductive nephrectomy).mp 10. (cytoreductive adj2 nephrectomy).mp 11. Cytoreduct*.mp 12. 9 OR 10 OR 11 13. 8 AND 12 LILACS (mh:"neoplasias renales" OR tw:"carcinoma renal") AND (mh:"nefrectomía" OR tw:"citoreductora") AND (mh:"ensayo clínico" OR tw:"doble ciego" OR tw:"experimento clínico" OR mh:"estudios de cohortes" OR mh:"Estudios de casos y controles")