was placed over Lympholyte M (Accurate, Westbury, NY) and centri- fuged at .... Meda L, Cassatella MA, Szendrel GI, Otvos Jr L, Baron P, Villalba M,. Ferrari D ...
May 22, 2013 - Hanna E. Auvinen1,4*., Yanan Wang1,4., Hans Princen2, Johannes A. ...... Dekkers OM, Biermasz NR, Pereira AM, Roelfsema F, van Aken MO, ...
Mar 7, 2006 - Torrance, CA 90509; **Division of Laboratory Animal Medicine, University of California, 924 Westwood Boulevard, Los Angeles, CA ...
pathology in young adult APPswe/PS1dE9 mice. Yan-Fang Mao,* Zhangyu Guo,* Tingting Zheng, Yasi Jiang,. Yaping Yan, Xinzhen Yin, Yanxing Chen and ...
In the acidic bile acid synthetic pathway, Cyp27a1 converts cholesterol into both 27-hydroxycholesterol and 3β-hydroxy-. 5-cholestenoic acid. The probe set for ...
Aug 21, 2010 - 1School of Pharmacy & Health Professions, Creighton University, 2500 California Plaza, ..... 15 Nowacek AS, Miller RL, McMillan J et al.
Jul 23, 2008 - Eckmann13, Marco Giovannini9, Vincent Ollendorff4,5, Hans Wolf-Watz3, Jean-Pierre ..... calculated using the Reed-Munch method [32].
Aug 28, 2014 - mouse Dock4, Lrrn3, Dnajb9, Immp2l exons 3â6 and Immp2l exons. 3â7 have been described previously [9]. Pbip gene was used as the.
Mar 14, 2014 - Pattern of neurobehavioral and organ-specific toxicities of β, β'-iminodipropionitrile in mice. Haseeb Ahmad Khan1, Khalid Elfakki Ibrahim2.
Sep 7, 2016 - United States of America, 3 Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, United States of ...... Nature reviews Rheumatology.
Housing Pregnant Mice (Mus musculus) in Small Groups Facilitates the. Development of ... bernick & Alberts, 1987), or with littermates (Porter, 1990; Ryan ..... terial in general, and that their âapproach behaviorâ in the earlier tests was ...
Nov 17, 1995 - and two rounds of treatment with anti-Thy 1.2 mAb (clone. 30H-12) at 4°C followed ..... clonal anergy in vivo are also interesting with regards to.
Brain-derived neurotrophic factor (BDNF) affects the development of brain neurotransmitter systems, including dopamine and serotonin systems that are ...
Oct 14, 2013 - ... 5 Department of HPB-Transplant. Surgery, NIHR Comprehensive Biomedical Campus, Addenbrookes Hospital, Cambridge, United Kingdom.
utero exposure to 2â²-deoxycoformycin (pentostatin). Teratology 47, 17-27. Airhart, M. J., Robbins, C. M., Knudsen, T. B., Church, J. K. and Skalko,. R. G. (1996).
Sep 20, 2013 - Ely DL, Greene EG, Henry JP (1977) Effects of hippocampal lesion on ... McManus MF, Nasrallah IM, Pancoast MM, Wynshaw-Boris A, Golden ...
Jun 20, 2006 - ity of the δ antagonist [3H]naltrindole and potencies of selective agonists (SNC80 and deltorphin II) or the endogenous peptide. Met-enkephalin ...
Sep 4, 2014 - transcript, Xist, and four genes on the Y chromosome (Kdm5d,. Ddx3y, Eif2s3y, Uty). The differential expression analysis between males and ...
Dec 16, 2013 - Matsubara H, Hogan DE, Morgan EF, Mortlock DP, Einhorn TA, et al. (2012) ... website-translation of your paper to 50 world's leading languages.
Sep 11, 2012 - established, whereas in Wt1-deficient embryos the final fusion process between ... of Pleuropericardial Membranes in Tbx18- and Wt1-Deficient.
Jan 12, 2012 - samples with high statistical power has also indicated that only a limited number ..... mice [37] were generated at the Eleanor Roosevelt Institute.
female N57 with male N52 from Abbie CC Lathrop, Granby, Ma ,USA. Stocks were then received by Hall. Jackson Laboratory received stock from Hall in 1948, ...
Oct 1, 2013 - Jonathan C. Cohend,2, and Helen H. Hobbsa,b,d,2 ... Contributed by Helen H. Hobbs, August 16, 2013 (sent for review July 23, 2013).
KumamotoâShi, Kumamotoâken 8608556, Japan. Full list of author ...... Hayden MR, WhaleyâConnell A, Bender SB, Klein T, et al. Dipeptidyl peptiâ daseâ4 ...
Hasegawa et al. Cardiovasc Diabetol (2017) 16:154 https://doi.org/10.1186/s12933-017-0639-y
ORIGINAL INVESTIGATION
Cardiovascular Diabetology Open Access
DPP‑4 inhibition with linagliptin ameliorates the progression of premature aging in klotho−/− mice Yu Hasegawa1, Kenyu Hayashi1, Yushin Takemoto1, Cao Cheng1, Koki Takane1, Bowen Lin1, Yoshihiro Komohara2 and Shokei Kim‑Mitsuyama1*
Abstract Background: The potential of anti-aging effect of DPP-4 inhibitors is unknown. This study was performed to deter‑ mine whether linagliptin, a DPP-4 inhibitor, could protect against premature aging in klotho−/− mice. Methods: Klotho−/− mice exhibit multiple phenotypes resembling human premature aging, including extremely shortened life span, cognitive impairment, hippocampal neurodegeneration, hair loss, muscle atrophy, hypoglycemia, etc. To investigate the effect of linagliptin on these aging-related phenotypes, male klotho−/− mice were divided into two groups: (1) control group fed the standard diet, and (2) linagliptin group fed the standard diet containing linagliptin. Treatment with linagliptin was performed for 4 weeks. The effect of linagliptin on the above mentioned aging-related phenotypes was examined. Results: Body weight of klotho−/− mice was greater in linagliptin group than in control group (11.1 ± 0.3 vs 9.9 ± 0.3 g; P
