Sep 7, 2016 - United States of America, 3 Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, United States of ...... Nature reviews Rheumatology.
Jun 24, 2013 - According to theory in life-history and animal personality, individuals with high fitness ... Funding: This project was funded by the Swiss National Science .... cage representing an arena composed of nine compartments, a.
Sep 6, 2011 - Background: Schistosomiasis japonica is a zoonotic parasitic disease ... of Sj23LHDGST bivalent antigen from Schistosoma japonicum and.
Communicated by Andre Lwoff, February 26, 1987 (receivedfor review February 6, 1987). ABSTRACT ..... We thank C. Fabre for excellent secretarial assistance.
Grossmann,1 Markus F. Blaess,1 Anja Lueth, 4 Hans-Peter Deigner, 5. Michael ... receptor, subfam B, member 4. Receptor for .... activity. Nrg4 neuregulin 4.
Linda D. Siracusa,* W. Gregory Alvord,? Wendy A. Bickmore,* ...... Addison-. Wesley, Reading, Mass. SELDIN, M. F., T. A. HOWARD and. P. D'EUSTACHIO,.
Jul 10, 2017 - The patent search was done using the German patent website [38] with the terms ... the German one. ..... Deutsches Patent- und Markenamt.
Changes in Male Genital Organs o f Mice Exposed ... male genital organs in laboratory mammals has not yet been studied. ... Some dense clusters of Leydig.
May 22, 2013 - Trevor J. Biden2, Gregory J. Cooney2, Robert M. Graham1,3* ...... Bungay PJ, Potter JM, Griffin M (1984) The inhibition of glucose-stimulated.
KumamotoâShi, Kumamotoâken 8608556, Japan. Full list of author ...... Hayden MR, WhaleyâConnell A, Bender SB, Klein T, et al. Dipeptidyl peptiâ daseâ4 ...
Hasegawa et al. Cardiovasc Diabetol (2017) 16:154 https://doi.org/10.1186/s12933-017-0639-y
ORIGINAL INVESTIGATION
Cardiovascular Diabetology Open Access
DPP‑4 inhibition with linagliptin ameliorates the progression of premature aging in klotho−/− mice Yu Hasegawa1, Kenyu Hayashi1, Yushin Takemoto1, Cao Cheng1, Koki Takane1, Bowen Lin1, Yoshihiro Komohara2 and Shokei Kim‑Mitsuyama1*
Abstract Background: The potential of anti-aging effect of DPP-4 inhibitors is unknown. This study was performed to deter‑ mine whether linagliptin, a DPP-4 inhibitor, could protect against premature aging in klotho−/− mice. Methods: Klotho−/− mice exhibit multiple phenotypes resembling human premature aging, including extremely shortened life span, cognitive impairment, hippocampal neurodegeneration, hair loss, muscle atrophy, hypoglycemia, etc. To investigate the effect of linagliptin on these aging-related phenotypes, male klotho−/− mice were divided into two groups: (1) control group fed the standard diet, and (2) linagliptin group fed the standard diet containing linagliptin. Treatment with linagliptin was performed for 4 weeks. The effect of linagliptin on the above mentioned aging-related phenotypes was examined. Results: Body weight of klotho−/− mice was greater in linagliptin group than in control group (11.1 ± 0.3 vs 9.9 ± 0.3 g; P
