Microarray expression profiles of long non-coding RNAs in germinal ...
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Microarray expression profiles of long non-coding RNAs in germinal ...
development of germinal center B-cell (GCB)-like diffuse large B-cell lymphoma (DLBCL) remain largely unknown. We applied microarray technology to profile ...
ONCOLOGY REPORTS
Microarray expression profiles of long non-coding RNAs in germinal center-like diffuse large B-cell lymphoma HONG-YU GAO, BIN WU, WEI YAN, ZI-MU GONG, QI SUN, HUI-HAN WANG and WEI YANG Department of Hematology, Shengjing Hospital of China Medical University, Tiexi, Shenyang, Liaoning 110000, P.R. China Received January 30, 2017; Accepted June 28, 2017 DOI: 10.3892/or.2017.5821 Abstract. Long non-coding RNAs (lncRNAs) are continuously transcribed and are involved in various cellular activities. However, their contributions to the occurrence and development of germinal center B-cell (GCB)-like diffuse large B-cell lymphoma (DLBCL) remain largely unknown. We applied microarray technology to profile the expression of lncRNAs in two different GCB-DLBCL cell lines (OCI-ly1 and OCI-ly19) and normal B lymphocytes. We demonstrated that 21,539 lncRNAs were expressed in all of the samples analyzed. This included 1,648 lncRNAs that showed a ≥2-fold upregulation and 2,671 lncRNAs that displayed a ≥2-fold downregulation in tumor cell lines (P
