Microsoft PowerPoint - 120302 suppl figure 1 ...

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GMP. PRPP-. PRPp. amidotransferase synthase. PRPP*. + Glutamine. PRA ... GMP kinase. GMP reductase. ΧΟ / ΑΟ. 6-TGDP. 6-TU. RNR. 6-TITP. 6-TGNs.
Ribose-5-P

PRPPsynthase

PRPPamidotransferase + Glutamine

PRPP

GMP

PRA

IMP

6-meTG

AMP

TPMT

6-TG

+SAM

6-meMP

Guanase

meTIMP

+SAM

AO

6-TU

+ GSH

6-MP

XO / AO

6-TU

+SAM

6-TIMP Kinases

AZA

HGPRT

ITPase

GST

TPMT

6-TX

HGPRT IMPDH + NAD

XO

GMPS + Glutamine + ATP

6-TXMP

6-TGMP

6-TU

GMP kinase

GMP reductase

6-TGDP RNR

6-TITP

ITPase

TPMT

6-TGNs 6-dTGDP NDPK

6-dTGTP 6-TGTP DNA and RNA synthesis