1D); the titers rose after viral RNA loads had increased and before CD4 T-cell counts fell below. * Corresponding author: Mailing address: Dana-Farber Cancer ...
JOURNAL OF VIROLOGY, May 2002, p. 5278–5284 0022-538X/02/$04.00⫹0 DOI: 10.1128/JVI.76.10.5278–5284.2002 Copyright © 2002, American Society for Microbiology. All Rights Reserved.
Vol. 76, No. 10
Molecular Evolution of Human Immunodeficiency Virus env in Humans and Monkeys: Similar Patterns Occur during Natural Disease Progression or Rapid Virus Passage Regina Hofmann-Lehmann,1,2 Josef Vlasak,1 Agnès-Laurence Chenine,1,2 Pei-Lin Li,1,2 Timothy W. Baba,2,3 David C. Montefiori,4 Harold M. McClure,5 Daniel C. Anderson,5 and Ruth M. Ruprecht1,2* Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute,1 and Department of Medicine, Harvard Medical School,2 Boston, Massachusetts 02115; Division of Newborn Medicine, Tufts University School of Medicine, Boston, Massachusetts 021113; Center for AIDS Research, Department of Surgery, Duke University Medical Center, Durham, North Carolina 277104; and Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 303225 Received 11 October 2001/Accepted 12 February 2002
Neonatal rhesus macaque 95-3 was inoculated with nonpassaged simian-human immunodeficiency virus strain SHIV-vpuⴙ, which encodes env of the laboratory-adapted human immunodeficiency virus (HIV) strain IIIB and is considered nonpathogenic. CD4ⴙ T-cell counts dropped to
