Multiple wave vector diffusion experiments on restricted ... - ismrm
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Multiple wave vector diffusion experiments on restricted ... - ismrm
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Multiple wave vector diffusion experiments on restricted diffusion M. A. Koch1, J. Finsterbusch1 1
Dept. of Neurology, Neuroimage Nord, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
INTRODUCTION Most diffusion weighted imaging experiments use gradient pulses of a single direction between excitation and data acquisition, sometimes split into several gradient pulses to suppress eddy current effects. P. P. Mitra [1] developed a theoretical description of the MR signal when two successive gradient pulse pairs of different direction are used between excitation and acquisition (multiple wave vector diffusion weighting, MWV). In that description, the signal depends sinusoidally on the angle between the gradient directions if diffusion in the sample is restricted. The effect might be used to estimate the mean cell size in vivo in the human brain. The present study attempts to measure the described effect in a biological sample, as a first step towards in vivo application. MATERIALS AND METHODS If the mean time required for diffusion across a pore, τD, and the duration, δ, and separation, ∆, of the diffusion gradient pulses (see Fig. 1a) obey δ
