n=9 (6) n=11 (2) n=13 (8) n=7 (0) n=10 (8) n=10 (0) n=12 (8) n=8 (0) n

OS uc.35

EFS uc.35

100

100

90

down-expressed over-expressed

90

80

Survival probability (%)


n=11 (2) 70 down-expressed over-expressed

60 50 40

n=9 (6)

30

80 70 60

n=11 (4)

50 40

n=9 (6)

30

20

20 0

50

100 Months

150

200

0

50

OS uc.51 100

90 Survival probability (%)


200

100

80 down-expressed over-expressed

n=13 (8)

40

150

EFS uc.51

n=7 (0)

60

100 Months

20

n=7 (1)

80 70 60


50 40 30

n=13 (9)

20 0

10 0

50

100 Months

150

200

0

50

OS uc.58

100 Months

150

200

EFS uc.58

100

100

n=10 (1)

n=10 (0)

90



80 80 70 down-expressed over-expressed

60 50 40

60


40

20 30

n=10 (8)

20 0

50

n=10 (9)

0 100 Months

150

200

0

50

OS uc.64

100 Months

150

200

EFS uc.64

100

100

n=8 (0) 90 Survival probability (%)


90 80 70


60 50 40

n=8 (1)

80 70 down-expressed over-expressed

60 50 40 30

n=12 (8)

30

n=12 (9)

20 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.70

EFS uc.70

100

100 90

n=12 (2)

80



90

70 60


50 40 30 20

80 70

n=12 (4)


40 30 20

n=7 (6)

10

n=7 (6)

10 0

50

100 Months

150

200

0

50

100 Months

OS uc.81 100 90

n=12 (2)

80



90

70 60


50 40 30 20

80 70

n=12 (4)

60 50


40 30 20

n=7 (6)

10

n=7 (6)

10 0

50

100 Months

150

200

0

50

OS uc.84

100 Months

150

200

EFS uc.84

100

100

90

90

n=12 (2)

80



200

EFS uc.81

100


50 40 30 20

80 70

n=12 (4)

60 50


40 30 20

n=7 (6)

10

n=7 (6)

10 0

50

100 Months

150

200

0

50

OS uc.100

100 Months

150

200

EFS uc.100

100

100

n=11 (1)

90

90

n=11 (2)

80



150

70 60


50 40 30

80 70 60


50 40 30 20

n=9 (7)

20

n=9 (8)

10 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.121

EFS uc.121

100

100

90

90

80

80



n=9 (0)

down-expressed over-exprressed

70 60 50 40

n=11 (8)

30

n=9 (1)


50 40 30

n=11 (9)

20

20

10 0

50

100 Months

150

200

0

50

100 Months

OS uc.122 100

n=10 (1)



200

EFS uc.122

100

80 70


60 50 40

n=10 (2)

80 70 60


50 40 30

n=10 (7)

n=10 (8)

30

20 0

50

100 Months

150

200

0

50

100 Months

OS uc.129

150

200

EFS uc.129

100

100

90

90

n=13 (2)

80



150

70 60


50 40 30 20

80 70

n=13 (4)

60 50


40 30 20

n=7 (6)

10

n=7 (6)

10 0

50

100 Months

150

200

0

50

OS uc.165

100 Months

150

200

EFS uc.165

100

100

80

n=14 (3)

80



90


50 40 30

n=14 (4) 60 down-expressed over-expressed

40

n=6 (6)

20

n=6 (5)

20 10

0 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.167

EFS uc.167

100

100

n=15 (3)



80


40

n=5 (5)

n=15 (5)

60

40

20

20

0

0


n=5 (5) 0

50

100 Months

150

200

0

50

100 Months

OS uc.185 100

n=11 (1)

90

90

80



200

EFS uc.185

100


60 50 40 30

80

n=11 (2)

70 60 down-expressed overe-xpressed

50 40 30 20

n=9 (7)

20

n=9 (8)

10 0

50

100 Months

150

200

0

50

OS uc.189

100 Months

150

200

EFS uc.189

100

100

n=7 (0)

n=7 (1)



150


70 60 50

n=13 (8)

40

80


70 60 50 40

n=13 (9) 30

30 0

50

100 Months

150

200

0

50

OS uc.192

100 Months

150

200

EFS uc.192

100

100



80

60 down-expressed over-expressed 40

n=6 (6)

20

n=14 (4)


40

20

n=6 (6) 0

0 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.196

EFS uc.196

100

100

n=7 (7) Survival probability (%)


n=7 (1)

90


70 60 50

n=13 (8)

40


50 40

n=13 (9)

30

30

20 0

50

100 Months

150

200

0

50

100 Months

OS uc.200 100

n=9 (1)

90

90

80



200

EFS uc.200

100


60 50 40

80

n=9 (2) 70 60 down-expressed over-expressed

50 40 30

n=11 (7)

30

n=11 (8)

20

20

10 0

50

100 Months

150

200

0

50

100 Months

OS uc.209

150

200

EFS uc.209

100

100

n=9 (0) 90

90

80

80



150


60 50 40

n=11 (8)

30

n=9 (1)


50 40 30

n=11 (9)

20

20

10 0

50

100 Months

150

200

0

50

OS uc.210

100 Months

150

200

EFS uc.210

100

100



80


n=6 (6)

20

n=14 (4) 60


40

n=6 (6)

20

0

0 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.211

EFS uc.211

100

100

n=14 (2)




80


40

n=6 (6)

20

60

n=14 (4)

40

20

n=6 (6) 0

0 0

50

100 Months

150

200

0

50

OS uc.215

80 70


60 50 40 30

n=10 (1)



200

100

n=10 (0)

90


60 50 40 30 20

n=10 (8)

20

n=10 (9)

10 0

50

100 Months

150

200

0

50

OS uc.220 100

100

90

90

n=14 (3)

80 70 60


50 40 30

n=6 (5)

20

100 Months

150

200

EFS uc.220



150

EFS uc.215

100


80 70

n=14 (5)

60 50 40 30

n=6 (5)

20

10

10 0

50

100 Months

150

200

0

50

OS uc.235

100 Months

150

200

EFS uc.235

100

100

n=11 (1)

90 80 70


60 50 40 30




100 Months

80 70

n=11 (3)

60 50 40 30

n=9 (7)

20

n=9 (7)

20 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.236

EFS uc.236

100

100

n=11 (1) n=11 (2) 80

80



90

70 60


50 40 30


40

n=9 (8)

20

20

n=9 (7)

10

0 0

50

100 Months

150

200

0

50

100 Months

OS uc.254

150

200

EFS uc.254

100

100

n=9 (0)

n=9 (0)




60 50 40


60

40

20

n=11 (8)

30

n=11 (10)

20

0 0

50

100 Months

150

200

0

50

100 Months

OS uc.265

200

EFS uc.265

100

100

n=11 (1)

90 80 70


60 50 40 30




150

80 70

n=11 (3) 60 50 40 30

n=9 (7)

20

n=9 (7)

20 0

50

100 Months

150

200

0

50

100 Months

OS uc.269

150

200

EFS uc.269

100

100

90

90

80

80

70



n=8 (0)


60 50 40

n=12 (8)

30

n=8 (1)

70 60


50 40 30

n=12 (9) 20

20 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.271

EFS uc.271

100

100

n=11 (1)


60 50 40 30




90

80 70

n=11 (3)

60 50 40 30

n=9 (7)

20

n=9 (7)

20 0

50

100 Months

150

200

0

50

OS uc.290

150

200

EFS uc.290

100

100

n=15 (3)



100 Months


40

n=5 (5)

20

n=15 (5)

60

40


20

n=5 (5) 0

0 0

50

100 Months

150

200

0

50

OS uc.291

200

100

n=9 (1)



150

EFS uc.291

100


60 50

n=11 (7)

40

80

n=9 (2)

70 60


50 40

n=11 (8)

30

30

20 0

50

100 Months

150

200

0

50

OS uc.307

100 Months

150

200

EFS uc.307

100

100

n=11 (1)

90

90

80



100 Months


60 50 40 30

n=11 (2)

80 70


60 50 40 30 20

n=9 (7)

20

n=9 (8)

10 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.312 100

EFS uc.312 100

n=7 (0)




70 60 50

n=13 (8)

40

80

n=7 (1)

70 60


50 40

n=13 (9)

30

30

20 0

50

100 Months

150

200

0

50

OS uc.317

100 Months

150

200

EFS uc.317

100

100




70 60 50

n=13 (8)

40


80 70 60

n=7 (1)

50 40

n=13 (9) 30

30 0

50

100 Months

150

200

0

50

OS uc.321

100 Months

150

200

EFS uc.321

100

100

90

90

80

80

70



n=9 (0)


60 50 40 30

n=9 (2)

70 60


50 40 30

n=11 (8)

20

n=11 (8)

20 0

50

100 Months

150

200

0

50

OS uc.322

150

200

EFS uc.322

100

100

80

80

n=15 (4)



100 Months

60

40


20

60

n=15 (6)


n=4 (4)

n=4 (4)

0

0 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.323

EFS uc.323

100

100

n=8 (0) down-expressed over-expressed




70 60 50 40

80 70

n=8 (2)

60 50 40

n=12 (8)

n=12 (8)

30

30 0

50

100 Months

150

200

0

50

100 Months

OS uc.330 100

n=8 (0)

90

80



90


60 50 40

n=12 (8)

30

80

n=8 (2)

70 60 50


40 30

20

n=12 (8)

20 0

50

100 Months

150

200

0

50

100 Months

OS uc.367 100

100

90

90

n=14 (3)

80 70 60


50 40 30

n=6 (5)

20

150

200

EFS uc.367



200

EFS uc.330

100


80 70

n=14 (5)

60 50 40 30

n=6 (5)

20

10

10 0

50

100 Months

150

200

0

50

100 Months

OS uc.371

150

200

EFS uc.371

100

100

n=11 (1)

90

90

80



150


50 40 30

n=9 (7)

20

80 70

n=11 (3)


40 30

n=9 (7)

20

10

10 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.374

EFS uc.374

100

100

90

90

80



n=12 (2) 70 60


50 40 30

80 70

n=12 (4)

60 50


40 30

n=8 (6)

20

n=8 (6)

20 0

50

100 Months

150

200

0

50

100 Months

100

100

90

90

80

n=13 (3)


50 40 30


80 70 60

n=13 (5)

50 40

n=7 (5)

30

n=7 (5)

20

20 0

50

100 Months

150

200

0

50

100 Months

OS uc.391

200

100

n=9 (1)


60 50

n=11 (7)

40




150

EFS uc.391

100

80 70 60

n=9 (3) 50

n=11 (7)

40

30

30 0

50

100 Months

150

200

0

50

100 Months

OS uc.406

150

200

EFS uc.406

100

100

n=11 (1)

90

90

80



200

EFS uc.376



OS uc.376

150


60 50 40 30

80

n=11 (2)


40 30 20

n=9 (7)

20

n=9 (8)

10 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.411

EFS uc.411

100

100



80 80

n=15 (4) 70 60 down-expressed over-expressed

50 40

n=15 (5)

60

40


20 30

n=5 (5) n=5 (4)

20 0

50

0 100 Months

150

200

0

50

OS uc.421

100 Months

150

200

EFS uc.421

100

100



80


40

n=6 (6)

20

n=14 (4) 60


20

n=6 (6) 0

0 0

50

100 Months

150

200

0

50

OS uc.423

200

100

90

90

n=13 (2)

80



150

EFS uc.423

100


50 40 30 20

80 70

n=13 (4) 60 50 40


30 20

n=7 (6)

10

n=7 (6)

10 0

50

100 Months

150

200

0

50

OS uc.435

100 Months

150

200

EFS uc.435

100

100

n=10 (1)

90 80 70


60 50 40

n=10 (7)

30




100 Months

80 70

n=10 (3)

60 50 40

n=10 (7)

30

20

20 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.436

EFS uc.436

100

100

n=9 (1)


60 50 40

n=11 (7)

30




90

80 70

n=9 (3)

60 50 40

n=11 (7)

30

20

20 0

50

100 Months

150

200

0

50

100 Months

OS uc.444 100

n=10 (1)



90 80 70


60 50 40

80

n=10 (2)


50 40 30

n=10 (7)

n=10 (8)

30

20 0

50

100 Months

150

200

0

50

OS uc.452

100 Months

150

200

EFS uc.452

100

100 90

90

n=12 (2) 80



200

EFS uc.444

100

70 60


50 40 30

n=8 (6)

80

n=12 (3)

70 60 50


40 30 20

20

n=8 (7)

10 0

50

100 Months

150

200

0

50

OS uc.467

100 Months

150

200

EFS uc.467

100

100

90


90

n=12 (2) 80



150

70 60


50 40 30

80 70 60

n=12 (4)

50 40 30

n=8 (6)

20

n=8 (6)

20 0

50

100 Months

150

200

0

50

100 Months

150

200

OS uc.469

EFS uc.469

100

100

n=11 (1)


60 50 40 30




90

80 70

n=11 (3) 60 50 40 30

n=9 (7)

20

n=9 (7)

20 0

50

100 Months

150

200

0

50

OS uc.477

100 Months

150

200

EFS uc.477

100

100



90 80 70


60 50 40

80

n=8 (1)


50 40 30

n=12 (8) 30

n=12 (9)

20 0

50

100 Months

150

200

0

50

100 Months

150

200

n=9 (6) n=11 (2) n=13 (8) n=7 (0) n=10 (8) n=10 (0) n=12 (8) n=8 (0) n

n=9 (6) n=11 (2) n=13 (8) n=7 (0) n=10 (8) n=10 (0) n=12 (8) n=8 (0) n

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