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n=9 (6) n=11 (2) n=13 (8) n=7 (0) n=10 (8) n=10 (0) n=12 (8) n=8 (0) n
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n=9 (6) n=11 (2) n=13 (8) n=7 (0) n=10 (8) n=10 (0) n=12 (8) n=8 (0) n
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60. 50. 40. 30. 20. Months. S u rv iv a. l p ro b a b ility. (%. ) down-expressed over-expressed n=
9
(6) n=11 (4) n=
13
(
9
) n=7 (1) n=10 (
9
) n=10 (1) n=
12
(
9
) n=
8
(1) ...
OS uc.35
EFS uc.35
100
100
90
down-expressed over-expressed
90
80
Survival probability (%)
Survival probability (%)
n=11 (2) 70 down-expressed over-expressed
60 50 40
n=9 (6)
30
80 70 60
n=11 (4)
50 40
n=9 (6)
30
20
20 0
50
100 Months
150
200
0
50
OS uc.51 100
90 Survival probability (%)
Survival probability (%)
200
100
80 down-expressed over-expressed
n=13 (8)
40
150
EFS uc.51
n=7 (0)
60
100 Months
20
n=7 (1)
80 70 60
down-expressed over-expressed
50 40 30
n=13 (9)
20 0
10 0
50
100 Months
150
200
0
50
OS uc.58
100 Months
150
200
EFS uc.58
100
100
n=10 (1)
n=10 (0)
90
Survival probability (%)
Survival probability (%)
80 80 70 down-expressed over-expressed
60 50 40
60
down-expressed over-expressed
40
20 30
n=10 (8)
20 0
50
n=10 (9)
0 100 Months
150
200
0
50
OS uc.64
100 Months
150
200
EFS uc.64
100
100
n=8 (0) 90 Survival probability (%)
Survival probability (%)
90 80 70
down-expressed over-expressed
60 50 40
n=8 (1)
80 70 down-expressed over-expressed
60 50 40 30
n=12 (8)
30
n=12 (9)
20 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.70
EFS uc.70
100
100 90
n=12 (2)
80
Survival probability (%)
Survival probability (%)
90
70 60
down-expressed over-expressed
50 40 30 20
80 70
n=12 (4)
60 50 down-expressed over-expressed
40 30 20
n=7 (6)
10
n=7 (6)
10 0
50
100 Months
150
200
0
50
100 Months
OS uc.81 100 90
n=12 (2)
80
Survival probability (%)
Survival probability (%)
90
70 60
down-expressed over-expressed
50 40 30 20
80 70
n=12 (4)
60 50
down-expressed over-expressed
40 30 20
n=7 (6)
10
n=7 (6)
10 0
50
100 Months
150
200
0
50
OS uc.84
100 Months
150
200
EFS uc.84
100
100
90
90
n=12 (2)
80
Survival probability (%)
Survival probability (%)
200
EFS uc.81
100
70 60 down-expressed over-expressed
50 40 30 20
80 70
n=12 (4)
60 50
down-expressed over-expressed
40 30 20
n=7 (6)
10
n=7 (6)
10 0
50
100 Months
150
200
0
50
OS uc.100
100 Months
150
200
EFS uc.100
100
100
n=11 (1)
90
90
n=11 (2)
80
Survival probability (%)
Survival probability (%)
150
70 60
down-expressed over-expressed
50 40 30
80 70 60
down-expressed over-expressed
50 40 30 20
n=9 (7)
20
n=9 (8)
10 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.121
EFS uc.121
100
100
90
90
80
80
Survival probability (%)
Survival probability (%)
n=9 (0)
down-expressed over-exprressed
70 60 50 40
n=11 (8)
30
n=9 (1)
70 60 down-expressed over-expressed
50 40 30
n=11 (9)
20
20
10 0
50
100 Months
150
200
0
50
100 Months
OS uc.122 100
n=10 (1)
90 Survival probability (%)
90 Survival probability (%)
200
EFS uc.122
100
80 70
down-expressed over-expressed
60 50 40
n=10 (2)
80 70 60
down-expressed over-expressed
50 40 30
n=10 (7)
n=10 (8)
30
20 0
50
100 Months
150
200
0
50
100 Months
OS uc.129
150
200
EFS uc.129
100
100
90
90
n=13 (2)
80
Survival probability (%)
Survival probability (%)
150
70 60
down-expressed over-expressed
50 40 30 20
80 70
n=13 (4)
60 50
down-expressed over-expressed
40 30 20
n=7 (6)
10
n=7 (6)
10 0
50
100 Months
150
200
0
50
OS uc.165
100 Months
150
200
EFS uc.165
100
100
80
n=14 (3)
80
Survival probability (%)
Survival probability (%)
90
70 60 down-expressed over-expressed
50 40 30
n=14 (4) 60 down-expressed over-expressed
40
n=6 (6)
20
n=6 (5)
20 10
0 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.167
EFS uc.167
100
100
n=15 (3)
80 Survival probability (%)
Survival probability (%)
80
60 down-expressed over-expressed
40
n=5 (5)
n=15 (5)
60
40
20
20
0
0
down-expressed over-expressed
n=5 (5) 0
50
100 Months
150
200
0
50
100 Months
OS uc.185 100
n=11 (1)
90
90
80
Survival probability (%)
Survival probability (%)
200
EFS uc.185
100
70 down-expressed over-expressed
60 50 40 30
80
n=11 (2)
70 60 down-expressed overe-xpressed
50 40 30 20
n=9 (7)
20
n=9 (8)
10 0
50
100 Months
150
200
0
50
OS uc.189
100 Months
150
200
EFS uc.189
100
100
n=7 (0)
n=7 (1)
90 Survival probability (%)
90 Survival probability (%)
150
80 down-expressed over-expressed
70 60 50
n=13 (8)
40
80
down-expressed over-expressed
70 60 50 40
n=13 (9) 30
30 0
50
100 Months
150
200
0
50
OS uc.192
100 Months
150
200
EFS uc.192
100
100
n=14 (2) 80 Survival probability (%)
Survival probability (%)
80
60 down-expressed over-expressed 40
n=6 (6)
20
n=14 (4)
60 down-expressed over-expressed
40
20
n=6 (6) 0
0 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.196
EFS uc.196
100
100
n=7 (7) Survival probability (%)
Survival probability (%)
n=7 (1)
90
90 80 down-expressed over-expressed
70 60 50
n=13 (8)
40
80 70 60 down-expressed over-expressed
50 40
n=13 (9)
30
30
20 0
50
100 Months
150
200
0
50
100 Months
OS uc.200 100
n=9 (1)
90
90
80
Survival probability (%)
Survival probability (%)
200
EFS uc.200
100
70 down-expressed over-expressed
60 50 40
80
n=9 (2) 70 60 down-expressed over-expressed
50 40 30
n=11 (7)
30
n=11 (8)
20
20
10 0
50
100 Months
150
200
0
50
100 Months
OS uc.209
150
200
EFS uc.209
100
100
n=9 (0) 90
90
80
80
Survival probability (%)
Survival probability (%)
150
70 down-expressed over-expressed
60 50 40
n=11 (8)
30
n=9 (1)
70 60 down-expressed over-expressed
50 40 30
n=11 (9)
20
20
10 0
50
100 Months
150
200
0
50
OS uc.210
100 Months
150
200
EFS uc.210
100
100
n=14 (2) 80 Survival probability (%)
Survival probability (%)
80
60 down-expressed over-expressed 40
n=6 (6)
20
n=14 (4) 60
down-expressed over-expressed
40
n=6 (6)
20
0
0 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.211
EFS uc.211
100
100
n=14 (2)
down-expressed over-expressed
80 Survival probability (%)
Survival probability (%)
80
60 down-expressed over-expressed
40
n=6 (6)
20
60
n=14 (4)
40
20
n=6 (6) 0
0 0
50
100 Months
150
200
0
50
OS uc.215
80 70
down-expressed over-expressed
60 50 40 30
n=10 (1)
90 Survival probability (%)
Survival probability (%)
200
100
n=10 (0)
90
80 70 down-expressed over-expressed
60 50 40 30 20
n=10 (8)
20
n=10 (9)
10 0
50
100 Months
150
200
0
50
OS uc.220 100
100
90
90
n=14 (3)
80 70 60
down-expressed over-expressed
50 40 30
n=6 (5)
20
100 Months
150
200
EFS uc.220
Survival probability (%)
Survival probability (%)
150
EFS uc.215
100
down-expressed over-expressed
80 70
n=14 (5)
60 50 40 30
n=6 (5)
20
10
10 0
50
100 Months
150
200
0
50
OS uc.235
100 Months
150
200
EFS uc.235
100
100
n=11 (1)
90 80 70
down-expressed over-expressed
60 50 40 30
down-expressed over-expressed
90 Survival probability (%)
Survival probability (%)
100 Months
80 70
n=11 (3)
60 50 40 30
n=9 (7)
20
n=9 (7)
20 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.236
EFS uc.236
100
100
n=11 (1) n=11 (2) 80
80
Survival probability (%)
Survival probability (%)
90
70 60
down-expressed over-expressed
50 40 30
60 down-expressed over-expressed
40
n=9 (8)
20
20
n=9 (7)
10
0 0
50
100 Months
150
200
0
50
100 Months
OS uc.254
150
200
EFS uc.254
100
100
n=9 (0)
n=9 (0)
90 Survival probability (%)
Survival probability (%)
80 80 70 down-expressed over-expressed
60 50 40
down-expressed over-expressed
60
40
20
n=11 (8)
30
n=11 (10)
20
0 0
50
100 Months
150
200
0
50
100 Months
OS uc.265
200
EFS uc.265
100
100
n=11 (1)
90 80 70
down-expressed over-expressed
60 50 40 30
down-expressed over-expressed
90 Survival probability (%)
Survival probability (%)
150
80 70
n=11 (3) 60 50 40 30
n=9 (7)
20
n=9 (7)
20 0
50
100 Months
150
200
0
50
100 Months
OS uc.269
150
200
EFS uc.269
100
100
90
90
80
80
70
Survival probability (%)
Survival probability (%)
n=8 (0)
down-expressed over-expressed
60 50 40
n=12 (8)
30
n=8 (1)
70 60
down-expressed over-expressed
50 40 30
n=12 (9) 20
20 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.271
EFS uc.271
100
100
n=11 (1)
80 70 down-expressed over-expressed
60 50 40 30
down-expressed over-expressed
90 Survival probability (%)
Survival probability (%)
90
80 70
n=11 (3)
60 50 40 30
n=9 (7)
20
n=9 (7)
20 0
50
100 Months
150
200
0
50
OS uc.290
150
200
EFS uc.290
100
100
n=15 (3)
80 Survival probability (%)
80 Survival probability (%)
100 Months
60 down-expressed over-expressed
40
n=5 (5)
20
n=15 (5)
60
40
down-expressed over-expressed
20
n=5 (5) 0
0 0
50
100 Months
150
200
0
50
OS uc.291
200
100
n=9 (1)
90 Survival probability (%)
90 Survival probability (%)
150
EFS uc.291
100
80 70 down-expressed over-expressed
60 50
n=11 (7)
40
80
n=9 (2)
70 60
down-expressed over-expressed
50 40
n=11 (8)
30
30
20 0
50
100 Months
150
200
0
50
OS uc.307
100 Months
150
200
EFS uc.307
100
100
n=11 (1)
90
90
80
Survival probability (%)
Survival probability (%)
100 Months
70 down-expressed over-expressed
60 50 40 30
n=11 (2)
80 70
down-expressed over-expressed
60 50 40 30 20
n=9 (7)
20
n=9 (8)
10 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.312 100
EFS uc.312 100
n=7 (0)
90 Survival probability (%)
Survival probability (%)
90 80 down-expressed over-expressed
70 60 50
n=13 (8)
40
80
n=7 (1)
70 60
down-expressed over-expressed
50 40
n=13 (9)
30
30
20 0
50
100 Months
150
200
0
50
OS uc.317
100 Months
150
200
EFS uc.317
100
100
n=7 (0) 90 Survival probability (%)
Survival probability (%)
90 80 down-expressed over-expressed
70 60 50
n=13 (8)
40
down-expressed over-expressed
80 70 60
n=7 (1)
50 40
n=13 (9) 30
30 0
50
100 Months
150
200
0
50
OS uc.321
100 Months
150
200
EFS uc.321
100
100
90
90
80
80
70
Survival probability (%)
Survival probability (%)
n=9 (0)
down-expressed over-expressed
60 50 40 30
n=9 (2)
70 60
down-expressed over-expressed
50 40 30
n=11 (8)
20
n=11 (8)
20 0
50
100 Months
150
200
0
50
OS uc.322
150
200
EFS uc.322
100
100
80
80
n=15 (4)
Survival probability (%)
Survival probability (%)
100 Months
60
40
down-expressed over-expressed
20
60
n=15 (6)
40 down-expressed over-expressed 20
n=4 (4)
n=4 (4)
0
0 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.323
EFS uc.323
100
100
n=8 (0) down-expressed over-expressed
90 Survival probability (%)
Survival probability (%)
90 80 down-expressed over-expressed
70 60 50 40
80 70
n=8 (2)
60 50 40
n=12 (8)
n=12 (8)
30
30 0
50
100 Months
150
200
0
50
100 Months
OS uc.330 100
n=8 (0)
90
80
Survival probability (%)
Survival probability (%)
90
70 down-expressed over-expressed
60 50 40
n=12 (8)
30
80
n=8 (2)
70 60 50
down-expressed over-expressed
40 30
20
n=12 (8)
20 0
50
100 Months
150
200
0
50
100 Months
OS uc.367 100
100
90
90
n=14 (3)
80 70 60
down-expressed over-expressed
50 40 30
n=6 (5)
20
150
200
EFS uc.367
Survival probability (%)
Survival probability (%)
200
EFS uc.330
100
down-expressed over-expressed
80 70
n=14 (5)
60 50 40 30
n=6 (5)
20
10
10 0
50
100 Months
150
200
0
50
100 Months
OS uc.371
150
200
EFS uc.371
100
100
n=11 (1)
90
90
80
Survival probability (%)
Survival probability (%)
150
70 60 down-expressed over-expressed
50 40 30
n=9 (7)
20
80 70
n=11 (3)
60 50 down-expressed over-expressed
40 30
n=9 (7)
20
10
10 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.374
EFS uc.374
100
100
90
90
80
Survival probability (%)
Survival probability (%)
n=12 (2) 70 60
down-expressed over-expressed
50 40 30
80 70
n=12 (4)
60 50
down-expressed over-expressed
40 30
n=8 (6)
20
n=8 (6)
20 0
50
100 Months
150
200
0
50
100 Months
100
100
90
90
80
n=13 (3)
70 60 down-expressed over-expressed
50 40 30
down-expressed over-expressed
80 70 60
n=13 (5)
50 40
n=7 (5)
30
n=7 (5)
20
20 0
50
100 Months
150
200
0
50
100 Months
OS uc.391
200
100
n=9 (1)
80 70 down-expressed over-expressed
60 50
n=11 (7)
40
down-expressed over-expressed
90 Survival probability (%)
90 Survival probability (%)
150
EFS uc.391
100
80 70 60
n=9 (3) 50
n=11 (7)
40
30
30 0
50
100 Months
150
200
0
50
100 Months
OS uc.406
150
200
EFS uc.406
100
100
n=11 (1)
90
90
80
Survival probability (%)
Survival probability (%)
200
EFS uc.376
Survival probability (%)
Survival probability (%)
OS uc.376
150
70 down-expressed over-expressed
60 50 40 30
80
n=11 (2)
70 60 50 down-expressed over-expressed
40 30 20
n=9 (7)
20
n=9 (8)
10 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.411
EFS uc.411
100
100
90 Survival probability (%)
Survival probability (%)
80 80
n=15 (4) 70 60 down-expressed over-expressed
50 40
n=15 (5)
60
40
down-expressed over-expressed
20 30
n=5 (5) n=5 (4)
20 0
50
0 100 Months
150
200
0
50
OS uc.421
100 Months
150
200
EFS uc.421
100
100
n=14 (2) 80 Survival probability (%)
Survival probability (%)
80
60 down-expressed over-expressed
40
n=6 (6)
20
n=14 (4) 60
40 down-expressed over-expressed
20
n=6 (6) 0
0 0
50
100 Months
150
200
0
50
OS uc.423
200
100
90
90
n=13 (2)
80
Survival probability (%)
Survival probability (%)
150
EFS uc.423
100
70 60 down-expressed over-expressed
50 40 30 20
80 70
n=13 (4) 60 50 40
down-expressed over-expressed
30 20
n=7 (6)
10
n=7 (6)
10 0
50
100 Months
150
200
0
50
OS uc.435
100 Months
150
200
EFS uc.435
100
100
n=10 (1)
90 80 70
down-expressed over-expressed
60 50 40
n=10 (7)
30
down-expressed over-expressed
90 Survival probability (%)
Survival probability (%)
100 Months
80 70
n=10 (3)
60 50 40
n=10 (7)
30
20
20 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.436
EFS uc.436
100
100
n=9 (1)
80 70 down-expressed over-expressed
60 50 40
n=11 (7)
30
down-expressed over-expressed
90 Survival probability (%)
Survival probability (%)
90
80 70
n=9 (3)
60 50 40
n=11 (7)
30
20
20 0
50
100 Months
150
200
0
50
100 Months
OS uc.444 100
n=10 (1)
90 Survival probability (%)
Survival probability (%)
90 80 70
down-expressed over-expressed
60 50 40
80
n=10 (2)
70 60 down-expressed over-expressed
50 40 30
n=10 (7)
n=10 (8)
30
20 0
50
100 Months
150
200
0
50
OS uc.452
100 Months
150
200
EFS uc.452
100
100 90
90
n=12 (2) 80
Survival probability (%)
Survival probability (%)
200
EFS uc.444
100
70 60
down-expressed over-expressed
50 40 30
n=8 (6)
80
n=12 (3)
70 60 50
down-expressed over-expressed
40 30 20
20
n=8 (7)
10 0
50
100 Months
150
200
0
50
OS uc.467
100 Months
150
200
EFS uc.467
100
100
90
down-expressed over-expressed
90
n=12 (2) 80
Survival probability (%)
Survival probability (%)
150
70 60
down-expressed over-expressed
50 40 30
80 70 60
n=12 (4)
50 40 30
n=8 (6)
20
n=8 (6)
20 0
50
100 Months
150
200
0
50
100 Months
150
200
OS uc.469
EFS uc.469
100
100
n=11 (1)
80 70 down-expressed over-expressed
60 50 40 30
down-expressed over-expressed
90 Survival probability (%)
Survival probability (%)
90
80 70
n=11 (3) 60 50 40 30
n=9 (7)
20
n=9 (7)
20 0
50
100 Months
150
200
0
50
OS uc.477
100 Months
150
200
EFS uc.477
100
100
n=8 (0) 90 Survival probability (%)
Survival probability (%)
90 80 70
down-expressed over-expressed
60 50 40
80
n=8 (1)
70 60 down-expressed over-expressed
50 40 30
n=12 (8) 30
n=12 (9)
20 0
50
100 Months
150
200
0
50
100 Months
150
200
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