Indian Journal Of Natural Sciences
www.tnsroindia.org. © IJONS
Vol.5 / Issue 28/ February 2015
International Bimonthly
ISSN: 0976 – 0997 RESEARCH ARTICLE
Naloxone-Precipitated Morphine Withdrawal in Male Miceis Attenuated by Acute Administration of Hydroalcoholic Extract of Cymbopogon Citratus (Lemon Grass) Hamed Ahmadi Sheikh Sarmast and Saeid Abbasi Maleki* Departement of Pharmacology, Urmia Branch, Islamic Azad University, Urmia, Iran.
Received: 22 Oct 2014
Revised: 21 Nov 2014
Accepted: 8 Dec 2014
*Address for correspondence Dr. Saeid Abbasi Maleki Departement of Pharmacology, Urmia Branch, Islamic Azad University, Urmia, Iran. Mobile: 098-9141130054 E-mail:
[email protected]
This is an Open Access Journal / article distributed under the terms of the Creative Commons Attribution License (CC BY-NC-ND 3.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. All rights reserved.
ABSTRACT
The present study was conducted to investigate the effect of hydroalcoholic extract ofCymbopogoncitratus (Lemon grass) on morphine withdrawal signs. Male NMRI mice (20-30g) were rendered dependent by intraperitoneal (i.p.) injections of morphine three times daily at doses of 50, 50 and 75 mg/kg, respectively, for 3 days. On day 4, after the last administration of morphine,different doses Of Cymbopogoncitratushydroalcoholic extract(140,280 and 560 mg/kg, i.p.) and fluoxetine (20mg/kg, i.p.) administered 30 min before administration of naloxone (5 mg/kg,i.p.).Mice were observed for 30 minutes for the withdrawal signs i.e., the characteristic jumping, grooming, teeth chattering, climbing, rearing, wet dog shakes, writing and diarrhea. Results of this study indicated that all dosesofCymbopogoncitratushydroalcoholic extract (p
