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Nanomedicine & Nanotechnology
Das et al., J Nanomed Nanotechnol 2014, 5:5 http://dx.doi.org/10.4172/2157-7439.1000235
Open Access
Research Article
Nanosilver-Mediated Change in Human Intestinal Microbiota Pranab Das1*, Julie AK McDonald2, Elaine O Petrof2, Emma Allen-Vercoe3 and Virginia K Walker1,4 Department of Biology, Queen’s University, Kingston, ON K7L 3N6, Canada Department of Medicine, Kingston General Hospital, Queen’s University, Kingston, ON K7L 2V7, Canada 3 Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada 4 Department of Biomedical and Molecular Sciences, and School of Environmental Studies, Queen’s University, Kingston, ON K7L 3N6, Canada 1 2
Abstract The widespread use of silver nanoparticles (AgNPs) has prompted studies on different species and at various trophic levels, however, little is known about possible toxicological impacts on their corresponding microbiota. Here the effects of AgNPs on a defined bacterial community established from the collected stool of a healthy donor have been investigated. The anaerobic consortium was exposed to several concentrations (0 – 200 mg/L) of AgNPs (capped; 10 nm) for 48 h. Nanosilver had a negative impact on the bacterial community as evidenced by a significant reduction (~22%) in culture-generated gas production at the two highest AgNP concentrations compared to controls, as well as significant (p
