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Potential link between ground water hardness, arsenic content and prevalence of CKDu Priyani A. Paranagama Senior Professor and Chair of Chemistry, Department of Chemistry, University of Kelaniya Highest prevalence of CKDu occurs in the largest rice farming areas in Sri Lanka and it is reported that approximately 99 % of CKDu patients are farmers(1). It was reported that source of drinking water of CKDu patients are obtained from dug wells (92 %) a nd tube wells (08 %)(2). Age of majority of the CKDu patients are between 30 – 40 years and they are heavily exposed to agrochemicals as very little attention is given to hazardous effects on human health(2). Our preliminary investigations revealed that significantly higher percentage of CKDu patients (p 21 g/g creatinine and significantly high concentration of arsenic has been observed in high keratin containing tissues such as hair and nails among the CKDu cases (p