Neuroprotective effect of Annona squamosa ... - Semantic Scholar
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Neuroprotective effect of Annona squamosa ... - Semantic Scholar
May 15, 2015 - 2015 Mayur Porwal and Arvind Kumar. This is an open access article distributed under the terms of the Creative Commons Attribution License ...
Journal of Applied Pharmaceutical Science Vol. 5 (Suppl 1), pp. 018-023, May, 2015 Available online at http://www.japsonline.com DOI: 10.7324/JAPS.2015.54.S4 ISSN 2231-3354
Neuroprotective effect of Annona squamosa & (-) Anonaine in decreased GABA receptor of epileptic rats Mayur Porwal, Arvind Kumar School of Pharmaceutical Sciences, IFTM University, Lodhipur-Rajput, Moradabad-244001, Uttar Pradesh, India.
ARTICLE INFO
ABSTRACT
Article history: Received on: 20/01/2015 Revised on: 18/02/2015 Accepted on: 21/03/2015 Available online: 15/05/2015
Annona squamosa and its active alkaloid content (-) Anonaine are known for antiepileptic activity on the basis of literature review. The objective of this study was to establish neuroprotection by Annona squamosa and its active alkaloid content (-) Anonaine as an antiepileptic agent by acting on GABA receptor. For neuroprotective assessment, variations of GABA, GABAA, GABAB receptors in the cortex region of the brain in epileptic rats and potential applications of Annona squamosa and its isolated chemical constituent (Anonaine) were investigated by using confocal microscopy. Nootropic activity in epileptic rats was also studied by radial and Y-maze model. GABA receptor binding analysis in the cortex region of epileptic rats showed significant decrease in Bmax (p
