Neutralizing Antibodies Do Not Mediate ... - Journal of Virology

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Jan 26, 2006 - Each diamond represents the diversity of env genes amplified from plasma viruses of ..... Burton, D. R. 2002. Antibodies, viruses ... 79:6528–6531. 10. Chun, T. W., L. Carruth, D. Finzi, X. Shen, J. A. DiGiuseppe, H. Taylor, M.
JOURNAL OF VIROLOGY, May 2006, p. 4758–4770 0022-538X/06/$08.00⫹0 doi:10.1128/JVI.80.10.4758–4770.2006 Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Vol. 80, No. 10

Neutralizing Antibodies Do Not Mediate Suppression of Human Immunodeficiency Virus Type 1 in Elite Suppressors or Selection of Plasma Virus Variants in Patients on Highly Active Antiretroviral Therapy Justin R. Bailey,1 Kara G. Lassen,1 Hung-Chih Yang,1 Thomas C. Quinn,1,2 Stuart C. Ray,1 Joel N. Blankson,1 and Robert F. Siliciano1,3* Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 212051; National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 208922; and Howard Hughes Medical Institute, Baltimore, Maryland 212053 Received 26 January 2006/Accepted 27 February 2006

Neutralizing antibodies (NAb) against autologous virus can reach high titers in human immunodeficiency virus type 1 (HIV-1)-infected patients with progressive disease. Less is known about the role of NAb in HIV-1-infected patients with viral loads of