New Concepts and Methods in Enzymology: From

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2015 Enzymes, Coenzymes and Metabolic Pathways (GRS) Seminar GRC

Enzymes, Coenzymes and Metabolic Pathways (GRS) Gordon Research Seminar

New Concepts and Methods in Enzymology: From Molecular Mechanisms to Industrial Applications July 11 - 12, 2015

Chairs Randy Kipp and Zhen Wang Waterville Valley 56 Packard's Road Waterville Valley, NH, US

Conference Description The Gordon Research Seminar on Enzymes, Coenzymes & Metabolic Pathways is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. The focus of this meeting will be on enzyme mechanisms and fundamental enzymology in industrial applications. This meeting will also emphasize career development, including a panel involving junior and senior representatives from academia and industry, as well as provide multiple opportunities to discuss cutting edge research and network in a casual, stimulating environment.

Related Meeting

This GRS will be held in conjunction with the "Enzymes, Coenzymes and Metabolic Pathways" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program Saturday https://www.grc.org/enzymes-coenzymes-and-metabolic-pathways-grs-conference/2015/

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2:00 pm - 5:00 pm

Arrival and Check-in

3:30 pm - 3:45 pm

Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair

3:45 pm - 4:30 pm

Keynote Session: Enzymes: Structure and Function Discussion Leader: Randy Kipp (Novartis Institutes for Biomedical Research, USA)

3:45 pm - 4:15 pm

Dan Herschlag (Stanford University, USA) "How Enzymes Work"

4:15 pm - 4:30 pm

Discussion

4:30 pm - 6:00 pm

Poster Session

6:00 pm

Dinner

7:30 pm - 9:30 pm

Fundamentals of Enzymatic Catalysis Discussion Leader: Sourav Roy (Jawaharlal Nehru Centre for Advanced Scienti c Research, India)

7:30 pm - 7:50 pm

Zahidul Islam (University of Iowa, USA) "Mechanistic Investigation of the Proton Abstraction in the Thymidylate Synthase-Catalyzed Reaction"

7:50 pm - 8:00 pm

Discussion

8:00 pm - 8:20 pm

Crystal Smitherman (Georgia State University, USA) "Excited State Proton Transfers in Flavoprotein Oxidases"

8:20 pm - 8:30 pm

Discussion

8:30 pm - 8:50 pm

Michael Funk (Massachusetts Institute of Technology, USA) "Substrate Recognition by the Radical Enzyme Benzylsuccinate Synthase"

8:50 pm - 9:00 pm

Discussion

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9:00 pm - 9:20 pm


Daniel Roston (University of Wisconsin, USA) "Enzymatic Phosphoryl Transfer: Reaction Pathways, Transition State Structures, and the Catalytic Roles of Arginine"

9:20 pm - 9:30 pm

Discussion

Sunday 7:30 am - 8:30 am

Breakfast

9:00 am - 11:00 am

Applications of Enzymology Discussion Leader: Shalinee Jha (Graz University of Technology, Austria)

9:00 am - 9:20 am

Emilia Arturo (Fox Chase Cancer Center / Drexel University College of Medicine, USA) "The First X-Ray Crystal Structure of Full-Length Mammalian Phenylalanine Hydroxylase"

9:20 am - 9:30 am

Discussion

9:30 am - 9:50 am

Hitomi Nakamura (Harvard University, USA) "Discovery and Characterization of the Cylindrocyclophane Biosynthetic Gene Cluster"

9:50 am - 10:00 am

Discussion

10:00 am - 10:20 am

Joao Pisco (Francis Crick Institute, United Kingdom) "Allosteric Control of M. tuberculosis ATPPhosphoribosyltransferase"

10:20 am - 10:30 am

Discussion

10:30 am - 10:50 am

Bharath Srinivasan (Georgia Institute of Technology, USA) "Prediction of Binding and Detailed Mechanistic Characterization of Novel Pyrroloquinazolinediamine Derivatives as Inhibitors of Escherichia coli Dihydrofolate Reductase"

10:50 am - 11:00 am

Discussion

11:00 am - 12:30 pm

Poster Session

https://www.grc.org/enzymes-coenzymes-and-metabolic-pathways-grs-conference/2015/

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Coffee will be served in the poster area from 11:00 am - 11:30 am

12:30 pm

Lunch

1:30 pm - 2:30 pm

Mentorship Component: Shaping Your Career in Academia or Industry Discussion Leader: Zhen Wang (Albert Einstein College of Medicine, USA)

1:30 pm - 2:30 pm

Panel Discussion "Perspectives from Junior and Veteran Investigators on Academic and Industrial Careers" Nozomi Ando (Princeton University, USA) Giovanni Gadda (Georgia State University, USA) Mark Hixon (Takeda California Inc., USA) Shuo Wang (Takeda California Inc., USA) Dan Herschlag (Stanford University, USA)

2:30 pm - 3:00 pm

Evaluation Period Fill in GRS Evaluation Forms

3:00 pm

Seminar Concludes

Contributors

The conference also gratefully acknowledges a contribution from Eudysmic Capital.

 https://www.grc.org/enzymes-coenzymes-and-metabolic-pathways-grs-conference/2015/

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