New Systemic Approaches in the Treatment of Metastatic Renal Cell ...
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18 New Systemic Approaches in the Treatment of Metastatic Renal Cell Carcinoma Thean Hsiang Tan1, Judith Lees1, Ganesalingam Pranavan2 and Desmond Yip2,3 1RAH
Cancer Centre, Royal Adelaide Hospital, Oncology Unit, The Canberra Hospital, 3ANU Medical School, Australian National University, Australia 2Medical
1. Introduction Cancer of the kidney comprises approximately 3% of all cancers in males and 2% in females according to Cancer Research UK statistics. (http://info.cancerresearchuk.org) Similar figures are seen globally. The majority (around 90%) of kidney cancers are Renal Cell Carcinomas (RCC), and clear cell carcinomas (adenocarcinomas) are the most common histological subtype. (Cohen & McGovern, 2005) The remaining 20-25% are papillary (Type I and II) (10-15%), chromophobe (4%) and collecting duct (including the rare medullary variant) (
