May 5, 2011 - silibinin, would prevent EMT and consequently invasiveness. Our results ... silibinin is in-part dependent on E-cadherin expression. Together ...
Nov 12, 2013 - possessing activities against kinases in the PI3K superfamily and identified a ... The class Ia phosphatidylinositol-3-kinase (PI3K) pathway is ...
Nov 12, 2013 - Omaha, NE, USA. Abstract .... cultured in 2 mL of modified medium-199 (Lonza eShop, Melnik, Czech Republic) [17] with penicillin (100 ...
Jan 16, 2012 - athymic nude mice (Charles River Laboratories). ... Hutchins G, Southward K, Handley K, Magill L, Beaumont C, Stahlschmidt J, et al. Value of.
Sep 9, 2009 - ... Leigh Zerbonia, Phillip Sunga, Jason Ptacekb, and Ann M. Arvina ...... Moffat JF, Greenblatt RJ (2010) Effects of varicella-zoster virus on cell ...
Jul 27, 2015 - Cyclophosphamide-induced vasopressin-independent activation of ... strated that, in the rat kidney, cyclophosphamide may activate V2R.
Jun 13, 2014 - Purpose Design and synthesis of a tumor responsive nanoparticle- based system ..... in mean particle size or particle size distribution (Fig. 1a).
Nov 14, 2013 - From the Departments of Pathology, Urology, and Radiation Oncology, the George Whipple Laboratory for Cancer Research, and the Wilmot ...
Oct 10, 2013 - outcome in children with opsoclonus-myoclonus associated with neuroblastoma: a report from the Pediatric Oncology Group. Med Pediatr ...
Apr 22, 2014 - activated in bleomycin-induced lung injury in mice, and whether targeting the Hedgehog-Gli pathway could decrease bleomycin- induced lung ...
Glucose induces autophagy under starvation conditions by a p38. MAPK-dependent .... p70S6K, P-MKK (MAPK kinase) 3/6 (Ser189/207), MKK3/6,. P-MKK4 ...
MSI uses only non-physiological sensors, such as measurement of forces, torques .... and a laptop computer running MATLAB Real Time Workshop for controller.
Feb 9, 2013 - We show that the modulation of current dACC activity by previous activity ... Subjects performed the multi-source interference task (MSIT)13, ...
Postdoctoral Fellow jointly appointed to the Department of Clinical Pharmacy and Outcomes ... Pharmaceutical patient assistance programs (PAPs) have the potential to .... (replaced by Research Portfolio Online Reporting Tools as of September 2009), O
To determine whether distinct neuronal groups were preferentially affected, we specifically used EG1285 .... of 400X. In Adobe Photoshop® 6.0.1 (Adobe Systems, Inc, San Jose, CA), the wand tool ..... Certification Core Manual. Washington ...
Cancer vaccines: current directions and perspectives in prostate ... Although no therapeutic cancer vaccine has yet been approved by the U.S. Food and Drug.
Sep 6, 2010 - 1To whom correspondence should be addressed: Ashley Felix, University of Pittsburgh Cancer Institute, Division of Cancer Prevention.
cancer, we monitored cancer incidence in the female lower reproductive tract of ... In the general population, 99% of cervical cancer, and more than 50% of anal, ...
Glioma; IDH1; α-ketoglutarate; 2-hydroxyglutarate; cancer metabolism; ..... Stand-Up-to-Cancer grant; Bayer Schering Grants for Targets; the JHU Brain Science ...
Dec 1, 2011 - 1 Center for Cancer Systems Biology (CCSB), Department of Cancer ... 3 Department of Biological Statistics and Computational Biology and ...
Family history of breast cancer and all-cause mortality after breast ... 14Cancer Epidemiology Centre, The Cancer Council Victoria, Carlton, Victoria, Australia.
Cognitive function in postmenopausal breast cancer patients ..... Australia: The Cancer Council Victoria, Melbourne: K. Wysman, S. Vickery, N. Ranieri, B.
Oct 14, 2011 - S6a), or beating cardiomyocytes (Movie S1âS2). Moreover ...... The human colon cancer methylome shows similar hypo- and hypermethylation.
Comprehensive Cancer Center â James Cancer Hospital and Solove ... human papillomavirus (HPV) is known to cause cancer, raises the possibility that GCA ...
Key resultsâCoronary arteriole myogenic tone was significantly reduced under EGFRtk,. GRB2-SOS, JAK, and STAT3 inhibition (53.6±2 vs. 83.4±1.3; 82.8±1; ...
NIH Public Access Author Manuscript Microvasc Res. Author manuscript; available in PMC 2012 January 1.
NIH-PA Author Manuscript
Published in final edited form as: Microvasc Res. 2011 January ; 81(1): 135–142. doi:10.1016/j.mvr.2010.11.001.
Mechanisms of Myogenic Tone of Coronary Arteriole: Role of Down Stream Signaling of the EGFR Tyrosine Kinase Ali H Amin, Zakaria Y Abd Elmageed, Megan Partyka, and Khalid Matrougui Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans LA-70112
Abstract
NIH-PA Author Manuscript
Background and purpose—We previously showed that epidermal growth factor receptor tyrosine kinase (EGFRtk) is essential in the development of myogenic tone. GRB2-SOS, protein kinase B (Akt), Janus kinase (JAK), and Signal Transducer and Activator of Transcription 3 (STAT3) are activated by stretch. Thus, we hypothesized that GRB2-SOS, Akt, JAK and STAT3 are downstream signaling of the EGFR and play role in myogenic tone. Experimental approach—Myogenic tone was determined in freshly isolated coronary arterioles from C57/BL6 mice with and without inhibitors. Pressurized coronary arterioles under 25 and 75 mm Hg were subjected to Western blot analysis to determine signaling phosphorylation. Smooth muscle cells (SMC) stimulated with EGF were used to determine the interaction between signaling. Key results—Coronary arteriole myogenic tone was significantly reduced under EGFRtk, GRB2-SOS, JAK, and STAT3 inhibition (53.6±2 vs. 83.4±1.3; 82.8±1; 83.6±1; 86.1±1 % of passive diameter at 75 mm Hg, p
