Nikolaidis et al. fig. S13 - PLOS

A

1000 900 800 700 600 500 400 300 200 100 0 MmL1

MmL2

MmD5

MmD4 MmD3A MmD3B MmD2A MmD2B MmD1A MmD1B MmD1C

Nikolaidis et al. fig. S13

B

transcripts per million

400

MmL1 MmL2 MmD5 MmD4 MmD3A MmD3B MmD2A MmD2B MmD1A MmD1B MmD1C

300 200 100

n sk i

bl oo d

sp le en

lu ng

er pa nc re as

liv

ga st r

te st is

ne oi nt ck es tin al tra ct

us

an d

th ym

he ad

ur in ar y

ow ar r m

tis su e

bo ne

em

m

am

m

br yo ni

c

ey e

in br a

ar y

gl an d

0

tissue

transcripts per million

C

300 M mL1 M mL2

200

M mD5 M mD4 M mD3A

100

M mD3B M mD2A M mD2B

0 pre-implantation embryo

mid-gestation embryo

late gestation embryo

fetus

neonate

juvenile

adult

M mD1A M mD1B M mD1C

developmental stage

Nikolaidis et al. fig. S13

D

transcripts per million

2000

1500

1000

500

0 HsD1A HsD1B HsD1C HsD4 HsD3A HsD3B HsD2A HsL1

HsL2

gene

Nikolaidis et al. fig. S13

ra to ga ry st ro in te st in al sk in tu m or no ngl io m a co lo re ct ge al rm ce ll tis su e

re sp i

gl io m a

pa nc re at ic

br ea st

le uk em ia

transcripts per million

F bl oo d

tis su e

m us cl

iv e

ov ar y

health state

liv er

ey e

co lo n

tis su e

ki dn ey

c

sk in

200

150

100

50

a

br ai n

te st is

lu ng

pl ac en t

ut er us

pa nc re as

em br yo ni

e pr os m ta am te m ar y gl an d

co nn ec t

st om ac h

trasripts per million

E 300

270

240

210

180

150

120

90 HsD1A HsD1B HsD1C HsD4 HsD3A HsD3B HsD2A HsL1 HsL2

60

30

0

tissue

250

HsD1A HsD1B HsD1C HsD4 HsD3A HsD3B HsD2A HsL1 HsL2

0

Nikolaidis et al. fig. S13