NOTES Antistaphylococcal Activity of a Cyclic Peptide ... - Europe PMC
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ANTIMICIROBIAL AGENTS AND CHEMOTHERAPY, Dec. 1986, 0066-4804/86/120938-02$02.00/0 Copyright C 1986, American Society for Microbiology
p. 938-939
Vol. 30, No. 6
NOTES
Antistaphylococcal Activity of a Cyclic Peptide, LY146032, and Vancomycin CYNTHIA C. KNAPP AND JOHN A. WASHINGTON II* Department of Microbiology, Cleveland Clinic Foundation, Cleveland, Ohio 44106 Received 4 June 1986/Accepted 19 September 1986
The inhibitory and bactericidal activities of a novel cyclic peptide antibiotic, LY146032, and vancomycin against oxacilln-susceptible and oxacillin-resistant staphylococci were compared. The MICs for 90% of strains were two- to fourfold higher for vancomycim than for LY146032. MBC/MIC ratios for all strains were 300 colonies to
